In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 29, No. 9 ( 2022-03), p. 1596-1605
Abstract:
PEPT1 is a vital member of the proton-dependent oligopeptide transporters
family (POTs). Many studies have confirmed that PEPT1 plays a critical role in the absorption of dipeptides, tripeptides, and pseudopeptides in the intestinal tract. In recent
years, several studies have found that PEPT1 is highly expressed in malignant tumor tissues and cells. The abnormal expression of PEPT1 in tumors may be closely related to the
progress of tumors, and hence, could be considered as a potential molecular biomarker for the diagnosis, treatment, and prognosis in malignant tumors. Furthermore, PEPT1 can be
used to mediate the targeted delivery of anti-tumor drugs. Herein, the expression, regulation, and role of PEPT1 in tumors in recent years have been reviewed.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867328666210707170214
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
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