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  • 1
    Online Resource
    Online Resource
    Bioactive Compounds from Mimosa pudica Leaves Extract with Their α- glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities in vitro and in silico Approaches
    Bentham Science Publishers Ltd. ; 2023
    In:  Letters in Drug Design & Discovery Vol. 20, No. 3 ( 2023-03), p. 353-364
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 20, No. 3 ( 2023-03), p. 353-364
    Abstract: 〈 p 〉 Background: Mimosa pudica Linn has been used in traditional medicine to support the treatment of type 2 diabetes. In the present study, we aimed to isolate and evaluate & #945;-glucosidase and Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activities of bioactive compounds from Mimosa pudica’s leaf extract. 〈 p 〉 Methods: Mimosa pudica leaves were extracted with 80% of ethanol. Bioactive compounds were isolated using a column chromatographic technique and elucidated the structure based on the nuclear magnetic resonance and electrospray ionization mass spectrometry spectral data. The & #945;- glucosidase and PTP1B inhibitory activities of the isolated compounds were evaluated using pnitrophenyl phosphate and p-nitrophenyl- & #945;-D-glucopyranoside as a substrate, respectively. Molecular docking and molecular dynamics are used to study the interaction between isolated compounds and proteins. Lipinski’s rule of five was used to evaluate the drug-like properties of isolated compounds. Predict pharmacokinetic parameters were evaluated using the pkCSM tool. 〈 p 〉 Results: Protocatechuic acid and syringic acid were isolated and identified using spectroscopic methods. Protocatechuic acid and syringic acid considerably inhibited & #945;-glucosidase enzyme at IC 〈 sub 〉 50 〈 /sub 〉 values of 416.17 ± 9.41 μM and 490.78 ± 9.28 μM, respectively. Furthermore, protocatechuic acid and syringic acid expressed strong PTP1B inhibitory activity at IC 〈 sub 〉 50 〈 /sub 〉 values of 248.83 ± 7.66 μM and 450.31 ± 7.77 μM, respectively. Molecular docking and molecular dynamics results showed the interactions of protocatechuic acid and syringic acid with amino acids of PTP1B and & #945;-glucosidase enzyme. Lipinski’s rule of five and absorption, distribution, metabolism, excretion, and toxicity studies predicted that protocatechuic acid and syringic acid have drug-likeness properties. In molecular docking simulation, protocatechuic acid and syringic acid gave relatively negative free binding energies and interacted with many amino acids in the active sites of PTP1B and & #945;-glucosidase. The molecular dynamics simulation results of the complexes were also relatively stable. 〈 p 〉 Conclusion: Our results showed that protocatechuic and syringic acids could be promising compounds for type 2 diabetes treatment. 〈 /p 〉
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/1570180819666220510105202
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Antidiabetic and Renoprotective Effects of Ethyl Acetate Fraction of Mimosa pudica Linn. Leaves Extract in Streptozotocin-Induced Diabetic Mice
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Bioactive Compounds Vol. 18, No. 10 ( 2022-12)
    Details
    In: Current Bioactive Compounds, Bentham Science Publishers Ltd., Vol. 18, No. 10 ( 2022-12)
    Abstract: Traditional medicine has used Mimosa pudica Linn. for diabetes treatment. This study evaluates the antidiabetic and renoprotective effects of the ethyl acetate fraction of M. pudica leaves on streptozotocin-induced diabetes in mice. Methods: The cold maceration method was used to extract M. pudica leaves with 80% ethanol at room temperature. Ethyl acetate (EtOAc) fraction was obtained from the M. pudica leaves extract by successively partitioning with different solvents. Mice were induced diabetes type 2 by streptozotocin (STZ) at a low dose and treated with EtOAc fraction of M. pudica leaves at 50 mg/kg and 100 mg/kg b.w for 60 days. After 24 hours of the final dose of therapy, the mice were sacrificed to extract blood and kidney tissues for biochemical and histopathological analysis. Results: The EtOAc fraction of M. pudica leaves showed strong activity in improving glucose concentration in the oral glucose tolerance test. Our results showed that EtOAc fraction significantly decreased levels of glucose, total cholesterol (TC), low-density lipoprotein (LDL), and triglyceride (TG) and increased the level of high-density lipoprotein (HDL), and protected kidneys against damage in mice. EtOAc fraction also increased the levels of antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), and decreased malondialdehyde (MDA) formation and pro-inflammatory cytokines (IL-1β and TNF-α) in kidney tissues. Moreover, the renoprotective effect was also observed in the histopathological analysis. Conclusion: Our findings support the fact that the EtOAc fraction of M. pudica leaves has potent anti-diabetic nephropathy activity by decreasing pro-inflammatory cytokines and improving antioxidant levels.
    Type of Medium: Online Resource
    ISSN: 1573-4072
    URL: Article
    DOI: 10.2174/1573407218666220307103828
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Regulation of Ecto-5´-Nucleotidase by Docosahexaenoic Acid in Human Endothelial Cells
    S. Karger AG ; 2013
    In:  Cellular Physiology and Biochemistry Vol. 32, No. 2 ( 2013), p. 355-366
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 32, No. 2 ( 2013), p. 355-366
    Type of Medium: Online Resource
    ISSN: 1421-9778 , 1015-8987
    URL: Article
    DOI: 10.1159/000354443
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells
    The Korean Physiological Society and The Korean Society of Pharmacology ; 2019
    In:  The Korean Journal of Physiology & Pharmacology Vol. 23, No. 5 ( 2019), p. 345-
    Details
    In: The Korean Journal of Physiology & Pharmacology, The Korean Physiological Society and The Korean Society of Pharmacology, Vol. 23, No. 5 ( 2019), p. 345-
    Type of Medium: Online Resource
    ISSN: 1226-4512 , 2093-3827
    URL: Article
    DOI: 10.4196/kjpp.2019.23.5.345
    Language: English
    Publisher: The Korean Physiological Society and The Korean Society of Pharmacology
    Publication Date: 2019
    detail.hit.zdb_id: 2526851-X
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Characterization and Optimization of Culture Conditions for Aurantiochytrium sp. SC145 Isolated from Sand Cay (Son Ca) Island, Vietnam, and Antioxidative and Neuroprotective Activities of Its Polyunsaturated Fatty Acid Mixture
    MDPI AG ; 2022
    In:  Marine Drugs Vol. 20, No. 12 ( 2022-12-14), p. 780-
    Details
    In: Marine Drugs, MDPI AG, Vol. 20, No. 12 ( 2022-12-14), p. 780-
    Abstract: Aurantiochytrium is a heterotrophic marine microalga that has potential industrial applications. The main objectives of this study were to isolate an Aurantiochytrium strain from Sand Cay (Son Ca) Island, Vietnam, optimize its culture conditions, determine its nutritional composition, extract polyunsaturated fatty acids (PUFAs) in the free (FFA) and the alkyl ester (FAAE) forms, and evaluate the antioxidation and neuroprotection properties of the PUFAs. Aurantiochytrium sp. SC145 can be grown stably under laboratory conditions. Its culture conditions were optimized for a dry cell weight (DCW) of 31.18 g/L, with total lipids comprising 25.29%, proteins 7.93%, carbohydrates 15.21%, and carotenoid at 143.67 µg/L of DCW. The FAAEs and FFAs extracted from Aurantiochytrium sp. SC145 were rich in omega 3–6–9 fatty acids (40.73% and 44.00% of total fatty acids, respectively). No acute or subchronic oral toxicity was determined in mice fed with the PUFAs in FFA or FAAE forms at different doses over 90 days. Furthermore, the PUFAs in the FFA or FAAE forms and their main constituents of EPA, DHA, and ALA showed antioxidant and AChE inhibitory properties and neuroprotective activities against damage caused by H2O2- and amyloid-ß protein fragment 25–35 (Aβ25-35)-induced C6 cells. These data suggest that PUFAs extracted from Aurantiochytrium sp. SC145 may be a potential therapeutic target for the treatment of neurodegenerative disorders.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md20120780
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175190-0
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum
    SAGE Publications ; 2023
    In:  Natural Product Communications Vol. 18, No. 3 ( 2023-03), p. 1934578X2311571-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 18, No. 3 ( 2023-03), p. 1934578X2311571-
    Abstract: Isolation, structure determination, and antimicrobial activities evaluation of compounds from the methanol extract of the marine microalga Thraustochytrium pachydermum TSL10. Methods Using chromatographic methods to isolate compounds from the methanol extract of the T pachydermum. The chemical structures were elucidated by analyses of HR-ESI-MS and NMR spectral data. The antimicrobial activities of compounds were evaluated using the dilution turbidimetric broth method as the standard protocol published by the Clinical and Laboratory Standard Institute. Results One new sterol, (24 R)-ergosta-7,22-diene-3 β,5 α,9 α-triol (1), and 16 known compounds, ergosta-7,22-diene-3 β,5 α-diol (2), cerevisterol (3), (22 E,24 S)-5 α,6 α-epoxy-ergosta-8(9),22-diene-3 β,7 α-diol (4), ergosterol (5), 5 α,8 α-epidioxyergosta-6,22-diene-3 β-ol (6), linoleic acid (7), 4-((9 Z,12 Z)-octadeca-9,12-dienoyloxy)butanoic acid (8), 1-linoleoyl-sn-glycero-3-phosphocholine (9), cibotiglycerol (10), gingerglycolipid B (11), oleic acid (12), 4-((9Z)-octadec-9-enoyloxy)butanoic acid (13), (2 S)-1- O-(9 Z)-octadec-9-enoyl)-3- O-(6-sulfo-D-quinovopyranosyl)glycerol (14), 6′- O-linoleylsucrose (15), gingerglycolipid C (16), and ( S)-3-stearoyl- sn-glycerol (17) were identified from the marine microalga Thraustochytrium pachydermum TSL10. Sterols 1–6 were found to exhibit significant antimicrobial activities on Gram-( + ) bacteria ( Enterococcus faecalis ATCC29212 , Staphylococcus aureus ATCC25923, and Bacillus cereus ATCC14579) and the yeast ( Candida albicans ATCC10231) with MIC values ranging from 32 to 256 µg/mL. Conclusions The results suggested sterols 1–6 could be potential antimicrobial agents against Gram-( + ) bacteria.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X231157145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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