In:
Drug Development Research, Wiley, Vol. 67, No. 12 ( 2006-12), p. 884-889
Abstract:
The aim of the present study was to evaluate the utility of pullulan acetate microparticles (PAMs), chitosan micropaticles (CMs), and dipalmitoylphosphatidyl‐serine‐liposomes (PS‐Lip) as oral carriers for delivery to the intestinal Peyer's patches (PPs). To monitor PP delivery after oral administration, PAMs, CMs, and PS‐Lip were radiolabeled with 99m Tc. Radiolabeling efficiencies of the particles were 95±2.5% (PAMs), 87±4.3% (CMs), and 77.2±5.8% (PS‐Lip). In delivery studies to the PPs, the percentage of PS‐Lip taken up to the PPs was 3.8 × 10 −3 ±0.3% of the administered dose with PS‐Lip group showed significantly high uptake compared to the PAM and CM groups. These results suggest that PS‐Lip may be used as a potential system for developing an oral delivery carrier. Drug Dev. Res. 67:884–889, 2006. © 2007 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0272-4391
,
1098-2299
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1500191-X
SSG:
15,3
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