In:
International Journal for Vitamin and Nutrition Research, Hogrefe Publishing Group, Vol. 80, No. 6 ( 2010-12-01), p. 369-377
Abstract:
The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n = 91) and a control group of examined patients with coronary arteries with no stenosis (n = 49)] . Between-group differences in continuous variables were analyzed with the Hotelling T 2 -test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes.
Type of Medium:
Online Resource
ISSN:
0300-9831
,
1664-2821
DOI:
10.1024/0300-9831/a000024
Language:
English
Publisher:
Hogrefe Publishing Group
Publication Date:
2010
SSG:
15,3
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