In:
Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 20, No. 16 ( 2020-11-10), p. 1574-1585
Abstract:
Blood coagulation is the process of changing the blood from the flowing state to the gel
state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated, and finally thrombin is formed to form fibrin clot. Direct
thrombin inhibitors are important anticoagulant drug. These drugs can selectively bind to the active site of thrombin, inhibit thrombin activity, have strong action and high specificity, and have important
significance in the clinical treatment of thrombus diseases. Some of them come from natural products of animals or plants, and many of them have been applied in the clinic. The other part is derived from the
design, synthesis and activity studies of small molecule inhibitors. This review discusses the progress of direct thrombin inhibitors in recent years.
Type of Medium:
Online Resource
ISSN:
1389-5575
DOI:
10.2174/1389557519666191015201125
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2020
SSG:
15,3
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