In:
Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 24, No. 10 ( 2023-08), p. 1213-1227
Abstract:
Small, non-coding microRNAs, usually of 20-25 nucleotides, are known to
regulate the post-transcriptional gene expression, which has a significant role in human biological processes, including immune-biogenesis, homeostasis and infection control as differential expression
of such miRNAs is responsible for fine-tuning the organismic development. Methods: A search of bibliographic databases was carried out with a focused question on microRNA-
Disease Prediction. A deductive qualitative content analysis approach was employed to assess the research's overall outcomes, review articles on prediction tools in miRNA-Diseases, and
analyse the interventions. Results: Diagnosis and therapeutics of diseases and miRNA prediction methods hold importance in
identifying the regulatory mechanisms. Collections of efficient miRNA prediction methods to identify miRNA-mRNA-disease regulatory relationships have been presented through this review, consolidating
the potential of miRNAs as a diagnostic and prognostic biomarker of multiple diseases, including COVID-19. Conclusions: The role of miRNA in the aetiology and pathogenesis of wide-range of pathologies,
including viral, bacterial to chronic diseases such as cancer, is quite feasible through the modern tools in bioinformatics which has been elaborated focusing upon miRNA-disease prediction methods
and their application potential establishing miRNAs as a robust and reliable biomarker in clinicomedical studies.
Type of Medium:
Online Resource
ISSN:
1389-2010
DOI:
10.2174/1389201024666221025114500
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
SSG:
15,3
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