In:
Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 16 ( 2021-11), p. 2250-2257
Abstract:
Cancer is a disease characterized by the invasion and uncontrolled growth of cells.
One of the best ways to minimize the harmful effects of mutagens is through the use of natural antimutagens. In this regard, the search for new antimutagens that act in the chemoprevention could represent a promising field
in this area. Objective: In this study biological potential of 11 fractions from Coccoloba uvifera L. leaf hexane extract was
evaluated by several in vitro tests. Methods: Leaves were lyophilized and hexane extraction was performed. The extract was fractionated by column
chromatography with hexane, ethyl acetate, and methanol. The antimutagenic (Ames test), antiproliferative (MTT test), and antioxidant capacity (DPPH, ABTS, and ferrous ion chelation) of the fractions were evaluated. Results:: Fractions 4, 6, 8, and 9 have antimutagenic activity (against sodium azide in strain TA100), fraction 11
showed antiproliferative capacity (IC 50 of 24 ± 9 μg/mL in cells of HCT 116). The fractions with the highest activity
were analyzed by HPLC-MS and lupeol, acacetin, and β-sitosterol were identified. Conclusion: This study demonstrates, for the first time, the bioactivity of C. uvifera leaf as a new source of
High Biological Value Compounds (HBVC), which can be of interest to the food and pharmaceutical industries.
Type of Medium:
Online Resource
ISSN:
1871-5206
DOI:
10.2174/1871520621999210104201242
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
detail.hit.zdb_id:
2217610-X
SSG:
15,3
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