In:
Alimentary Pharmacology & Therapeutics, Wiley, Vol. 24, No. 11-12 ( 2006-12), p. 1553-1561
Abstract:
Background Few data are available on the effect of antioxidants in paediatric non‐alcoholic fatty liver disease (NAFLD). Aim To compare the effect of a nutritional programme alone or combined with alpha‐tocopherol and ascorbic acid on alanine aminotransferase (ALT) levels, and insulin resistance (IR) in biopsy‐proven NAFLD children. Methods In a 12‐month double‐blind placebo study, 90 patients were prescribed a balanced calorie diet (25–30 cal/kg/d), physical exercise, and placebo (group A) or alpha‐tocopherol 600 IU/day plus ascorbic acid 500 mg/day (group B). IR was estimated by the homeostasis model assessment (HOMA‐IR). Results At month 12, ALT (32.67 ± 8.09 vs. 32.18 ± 11.39 IU/L; P = NS), HOMA‐IR (1.52 ± 0.66 vs. 1.84 ± 0.95 IU/L; P = NS), and weight loss (32% vs. 35% of excessive body weight; P = NS) did not differ between the two arms. Among subjects who lost ≥20% of their excessive weight, ALT and body weight percentage changes were significantly related ( r o = 0.260; P = 0.03). In subjects, who lost more than 1.0 kg, HOMA‐IR significantly decreased (2.20 ± 0.21 to 1.57 ± 0.13 in group A ( P ≤ 0.01; −8%); 2.91 ± 0.24 to 1.88 ± 0.16 in group B (−32%; P ≤ 0.0001)). ALT decreased by 36% (59.13 ± 4.11 vs. 30.27 ± 1.46 IU/L; P ≤ 0.001), and 42% (68.19 ± 5.68 vs. 31.92 ± 1.92 IU/L; P ≤ 0.0001). In a multivariate analysis, fasting insulin changes in group A ( P = 0.012; F = 7.150). Conclusions Diet and physical exercise in NAFLD children seem to lead to a significant improvement of liver function and glucose metabolism beyond any antioxidant therapy.
Type of Medium:
Online Resource
ISSN:
0269-2813
,
1365-2036
DOI:
10.1111/apt.2006.24.issue-11-12
DOI:
10.1111/j.1365-2036.2006.03161.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2003094-0
SSG:
15,3
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