In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 56, No. 8 ( 2012-08), p. 4140-4145
Abstract:
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro . Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis , including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo . Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.06445-11
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2012
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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