In:
Alimentary Pharmacology & Therapeutics, Wiley, Vol. 49, No. 2 ( 2019-01), p. 165-172
Abstract:
Although a higher risk of other immune‐mediated diseases has been reported in inflammatory bowel disease (IBD) patients, the risk factors of immune‐mediated diseases development and the effect of concomitant immune‐mediated diseases on outcomes remain poorly defined. Aim To determine the risk factors of incident immune‐mediated diseases and the impact of comorbid immune‐mediated diseases on outcomes in IBD. Methods Using the National Health Insurance claims data for the entire Korean population, we identified 35 581 IBD patients without immune‐mediated diseases and 595 IBD patients with immune‐mediated diseases from 2012 to 2013, and follow‐up until 2016. We selected four controls by age and sex for comparing with cases. Results A total of 35 581 IBD patients without immune‐mediated diseases and 142 324 matched controls without immune‐mediated diseases were followed from 2014 to 2016 and of these 239 IBD patients and 357 controls developed immune‐mediated disease. The overall immune‐mediated diseases risk was higher in IBD patients (HR, hazard ratio, 2.47; 95% confidence interval, CI, 2.09‐2.91). In a nested case‐control study of the IBD cohort, adult patients aged ≥20 years and frequent hospitalisation ≥1 per year were independent risk factors for incident immune‐mediated diseases, in contrast, 5‐aminosalicylic acid (5‐ASA) use had protective effect (odds ratio, 0.61; 95% CI, 0.41‐0.90) for developing immune‐mediated diseases. In addition, IBD patients with another immune‐mediated disease had an increased risk of needing anti‐TNF‐α agent (HR, 2.40; 95% CI, 2.02‐2.84) and developing acute flare (HR, 1.76; 95% CI, 1.37‐2.26). Conclusions The incidence of immune‐mediated diseases in IBD patients was higher than that of non‐IBD population. 5‐ASA use may reduce this risk.
Type of Medium:
Online Resource
ISSN:
0269-2813
,
1365-2036
DOI:
10.1111/apt.2019.49.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2003094-0
SSG:
15,3
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