In:
Autonomic and Autacoid Pharmacology, Wiley, Vol. 25, No. 4 ( 2005-10), p. 129-134
Abstract:
1 To investigate anti‐inflammatory activity of organic germanium, we measured the effect of germanium‐concentrated yeast on arachidonic acid release, prostaglandin E 2 (PGE 2 ) production, histamine release, and intracellular H 2 O 2 or hydroperoxide generation in RBL 2H3 cells, and carrageenan‐induced paw oedema in rats. 2 Germanium‐concentrated yeast dose‐dependently inhibited carrageenan‐induced paw oedema, suggesting that germanium‐concentrated yeast has anti‐inflammatory activity in acute inflammation. 3 Germanium‐concentrated yeast significantly inhibited melittin‐induced arachidonic acid release and PGE 2 production in RBL 2H3 cells. 4 Germanium‐concentrated yeast did not affect melittin‐induced histamine release and silica‐induced intracellular H 2 O 2 or hydroperoxide generation in RBL 2H3 cells. 5 These results suggest that anti‐inflammatory activity of germanium‐concentrated yeast appears partly to be related to the inhibition of arachidonic acid release and PGE 2 production in RBL 2H3 cells.
Type of Medium:
Online Resource
ISSN:
1474-8665
,
1474-8673
DOI:
10.1111/aap.2005.25.issue-4
DOI:
10.1111/j.1474-8673.2005.00335.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2115935-X
detail.hit.zdb_id:
2090847-7
SSG:
15,3
Permalink