In:
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 61, No. 12 ( 2018-10), p. 885-894
Abstract:
The aim of this study was to formulate and evaluate the freeze‐dried kit of NOTA‐hexavalent lactoside (NOTA‐HL) for the preparation of 68 Ga‐labeled glycoligand for PET imaging of the asialoglycoprotein receptor (ASGPR). 68 GaCl 3 was obtained from a commercial 68 Ge/ 68 Ga generator. Single‐vial kits of HL were formulated. Optimization of radiolabeling with 68 Ga, various evaluations of NOTA‐HL kits, and in vitro stability study of 68 Ga‐HL were carried out. PET/CT imaging of normal mice injected with 68 Ga‐NOTA‐HL was performed. NOTA‐HL kit was successfully formulated. High radiochemical yields ( 〉 95%) were obtained by 68 Ga radiolabeling. The NOTA‐HL kits were stable for at least 12 months, and 68 Ga‐NOTA‐HL exhibited good in vitro stability. PET studies in normal mice revealed high specific accumulation of activity in the liver. The NOTA‐HL kit was developed for fast 68 Ga labeling. 68 Ga‐NOTA‐HL showed high specific uptake in liver. The availability of ready‐to‐use NOTA‐HL kits combined with 68 Ge/ 68 Ga generators would provide an efficient approach for PET imaging of ASGPR.
Type of Medium:
Online Resource
ISSN:
0362-4803
,
1099-1344
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1491841-9
SSG:
15,3
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