In:
Medicinal Research Reviews, Wiley, Vol. 28, No. 2 ( 2008-03), p. 185-200
Abstract:
Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 185–200, 2008
Type of Medium:
Online Resource
ISSN:
0198-6325
,
1098-1128
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
603210-2
detail.hit.zdb_id:
2001841-1
SSG:
15,3
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