In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 43, No. 4 ( 1999-04), p. 963-965
Abstract:
Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (−0.33 ± 0.13 Δlog 10 CFU/ml · h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (−0.39 ± 0.18 Δlog 10 CFU/ml · h; i.v. administered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 μg/ml). The combination of both drugs significantly increased ( P 〈 0.05) the killing rate (−0.60 ± 0.23 Δlog 10 CFU/ml · h) compared to that produced by either monotherapy. These results were also confirmed in vitro.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.43.4.963
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1999
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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