In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 47, No. 12 ( 2003-12), p. 3699-3703
Abstract:
DQ-113
is a new quinolone with potent activity against gram-positive pathogens. The in vivo activity of DQ-113 against Streptococcus
pneumoniae was compared with those of gatifloxacin and
ciprofloxacin in a mouse model. For this purpose, two strains of S.
pneumoniae were used: penicillin-susceptible S.
pneumoniae (PSSP) and penicillin-resistant S. pneumoniae (PRSP). The survival rates of mice infected with PSSP and PRSP at 14
days after infection were 80% in the DQ-113-treated group and 0 to 10% in the other three groups. In murine infections caused by
PSSP, the 50% effective doses (ED 50 s) of DQ-113,
gatifloxacin, and ciprofloxacin were 6.0, 41.3, and 131.6 mg/kg, respectively. Against PRSP-caused pneumonia in mice, the
ED 50 s of DQ-113, gatifloxacin, and ciprofloxacin were 7.6,
64.7, and 125.9 mg/kg, respectively. Compared with the other drugs, DQ-113 showed excellent therapeutic efficacy and eradicated viable
bacteria in both PSSP- and PRSP-infected mice. The means ± standard errors of the means of viable bacterium counts in the lungs of
gatifloxacin-treated, ciprofloxacin-treated, and untreated control mice infected with PSSP were 2.91 ± 0.34, 3.13 ± 0.48, and
3.86 ± 0.80 log 10 CFU/ml, respectively. The same
counts in mice infected with PRSP treated with the same three agents were 6.57 ± 0.99, 6.54 ± 0.40, and 7.17 ± 0.43 log 10 CFU/ml, respectively. DQ-113 significantly decreased
the number of viable bacteria in the lungs compared with gatifloxacin and ciprofloxacin. Of the drugs analyzed, the
pharmacokinetic-pharmacodynamic parameter of area under the concentration-time curve (AUC)/MIC ratio for DQ-113 was significantly
higher than those for gatifloxacin and ciprofloxacin. Our results suggest that DQ-113 has potent in vivo efficacy against both PSSP and
PRSP.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.47.12.3699-3703.2003
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2003
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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