In:
Alimentary Pharmacology & Therapeutics, Wiley, Vol. 56, No. 2 ( 2022-07), p. 321-329
Abstract:
Non‐alcoholic fatty liver disease (NAFLD) is a major liver disease worldwide. Bile acid dysregulation may be a key feature in its pathogenesis and progression. Aims To characterise the relationship between bile acid levels and NAFLD at the population level Methods We conducted a cross‐sectional study in Guatemala in 2016 to examine the prevalence of NAFLD. Participants ( n = 415) completed questionnaires, donated blood samples and had a brief medical exam. NAFLD was determined by calculation of the fatty liver index. The levels of 15 circulating bile acids were determined by LC–MS/MS. Adjusted prevalence odds ratios (POR adj ) and 95% CI were calculated to examine the relationships between bile acid levels (in tertiles) and NAFLD. Results Persons with NAFLD had significantly higher levels of the conjugated primary bile acids glycocholic acid (GCA) (POR adj T3 vs T1 = 1.85), taurocholic acid (TCA) (POR adj T3 vs T1 = 2.45) and taurochenodeoxycholic acid (TCDCA) (POR adj T3 vs T1 = 2.10), as well as significantly higher levels the unconjugated secondary bile acid, deoxycholic acid (DCA) (POR adj T3 vs T1 = 1.78) and its conjugated form, taurodeoxycholic acid (TDCA) (POR adj T3 vs T1 = 1.81). Conclusions The bile acid levels of persons with and without NAFLD differed significantly. Among persons with NAFLD, higher levels of the conjugated forms of CA (i.e. GCA, TCA) and the secondary bile acids that derive from CA (i.e. DCA, TDCA) may indicate there is hepatic overproduction of CA, which may affect the liver via aberrant signalling mediated by the bile acids.
Type of Medium:
Online Resource
ISSN:
0269-2813
,
1365-2036
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2003094-0
SSG:
15,3
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