In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 30, No. 9 ( 2023-03), p. 1060-1085
Abstract:
2,5-Diketopiperazines (DKPs), also called cyclic dipeptides, are
the simplest peptide derivatives in nature that are formed by the condensation of two amino acids. They are an important category of bioactive substances with various structures. Objective: This review focuses on the natural sources, synthetic processes, biological
properties and MS fragmentation regularity of simple DKPs, in order to provide a reference for exploring future scientific and therapeutic potentials of these compounds. Method: Pertinent information was collected and organized from several electronic scientific
databases (e.g., Web of Science, China Knowledge Resource Integrated, ScienceDirect, PubMed, Wanfang Data and Google Scholar), PhD and MS dissertations.
There are 107 articles published from the early 20th century to 2021 that were reviewed in this work. Results: DKPs have been obtained from a broad range of natural resources, including fungi,
bacteria, plants, and animals, and have been synthesized by chemical and biological methods. DKPs have various pharmacological activities, including anticancer, antibacterial,
antithrombotic, neuron protective, analgesic, and other activities. Mass spectrometry is the most common method for the structural analysis of DKPs. DKPs can be quickly
screened and identified by MS according to the mass spectrum fragmentation pattern. Conclusion: As a category of relatively unexplored compounds, DKPs have been demonstrated
to have various bioactivities, especially with antitumor and antibacterial activities. However, the existing research on DKPs is still in the early stage, and their application in
drug development needs to be further studied.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867329666220801143650
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
SSG:
15,3
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