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  • 1
    Online Resource
    Online Resource
    Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis
    National Library of Serbia ; 2014
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 71, No. 4 ( 2014), p. 362-367
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 71, No. 4 ( 2014), p. 362-367
    Abstract: Background/Aim. Atherosclerosis is still the leading cause of death in Western world. Development of atherosclerotic plaque involves accumulation of inflammatory cells, lipids, smooth muscle cells and extracellular matrix proteins in the intima of the vascular wall. Apolipoprotein E participates in the transport of exogenous cholesterol, endogenouly synthesized lipids and triglycerides in the organism. Apolipoprotein E gene has been identified as one of the candidate genes for atherosclerosis. Previous studies in different populations have clearly implicated apolipoprotein E genetic variation (? polymorphisms) as a major modulator of low density lipoprotein cholesterol levels. Data considering apolipoprotein E polymorphisms in relation to carotid atherosclerosis gave results that are not in full compliance. The aim of present study was to investigate the apolipoprotein E polymorphisms in association with carotid plaque presence, apolipoprotein E and lipid serum levels in patients with carotid atherosclerosis from Serbia. Methods. The study group enrolled 495 participants: 285 controls and 210 consecutive patients with carotid atherosclerosis who underwent carotid endarterectomy. Genotyping of apolipoprotein E polymorphisms were done using polymerase chain reaction and restriction fragment length polymorphism methods. Results. Patients had significantly decreased frequency of the ?2 allele compared to controls. Patients who carry at least one ?2 allele had a significantly higher level of serum apolipoprotein E and significantly lower low density lipoprotein cholesterol levels compared to those who do not carry this allele. Conclusion. Our results suggest protective effect of apolipoprotein E ?2 allele on susceptibility for carotid plaque presence as well as low density lipoprotein cholesterol lowering effect in Serbian patients with carotid atherosclerosis. Further research of multiple gene and environmental factors that contribute to the appearance and the progression of atherosclerosis should be continued with respect to different populations.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP1404362Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
    Walter de Gruyter GmbH ; 2009
    In:  Clinical Chemistry and Laboratory Medicine Vol. 47, No. 12 ( 2009-01-01)
    Details
    In: Clinical Chemistry and Laboratory Medicine, Walter de Gruyter GmbH, Vol. 47, No. 12 ( 2009-01-01)
    Type of Medium: Online Resource
    ISSN: 1437-4331 , 1434-6621
    URL: Article
    DOI: 10.1515/CCLM.2009.343
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2009
    detail.hit.zdb_id: 1492732-9
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Potentially inappropriate medication prescribing among elderly patients with cardiovascular diseases
    National Library of Serbia ; 2022
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 79, No. 4 ( 2022), p. 373-382
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 79, No. 4 ( 2022), p. 373-382
    Abstract: Background/Aim. The growing number of older adults means higher medicine utilization. The aim of the study was to determine the frequency and identify risk factors of potentially inappropriate medication (PIM) in the elderly population with cardiovascular diseases. Methods. The retrospective, cross-sectional study was performed in 2018, and the relevant data were collected during the period from January 2016 to December 2017. The study sample included 1,500 patients over 65 years with cardiovascular disease who had medical records at the Institute for Gerontology and Palliative Care, Belgrade. Assessment of PIM was done by standard international criteria such as the American Geriatrics Society 2015 updated Beers Criteria for PIM use in older adults. Results. PIM frequency in the elderly population was 70.3%. In relation to gender, it was more frequent in female elders. The mean number of prescribed drugs was similar for 2016 and 2017, 7.2 and 7.3, respectively. The most common were: medium-acting benzodiazepines (70.9%), central ? blockers (23.98%), and antipsychotics (typical and atypical) (20.94%). The most common comorbidity was noted in a group labeled with the International Disease Classification I00-I99, which includes heart and blood vessel diseases [n = 2,658 (36.9%)]. The most common diagnoses belonged to the subgroups I10-I15 [hypertensive diseases, n = 1,298 (18%)], I20-I25 [ischemic heart diseases n = 542 (7.5%)], I30-I52 [other forms of heart disease, n = 705 (9.8%)], I60-I69 [cerebrovascular diseases, n = 94 (1.3%)], and I80- I89 [diseases of veins, lymph vessels, and lymph nodes n = 12 (0.17%)]. The risk factors for PIM were: polypharmacy, gender, nicotine use, cognitive status, nutrition state, and the number of diseases registered in the study sample. Conclusion. Cardiovascular diseases in the elderly population are associated with a high prevalence of PIM. Creating health recommendations for prescribing drugs to the elderly that would emphasize these factors could reduce the prevalence of PIM in this population.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP200623118S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2022
    detail.hit.zdb_id: 2169819-3
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  • 4
    Online Resource
    Online Resource
    Factors Associated with Potentially Inappropriate Prescribing in Patients on Peritoneal Dialysis
    S. Karger AG ; 2023
    In:  Pharmacology Vol. 108, No. 1 ( 2023), p. 1-7
    Details
    In: Pharmacology, S. Karger AG, Vol. 108, No. 1 ( 2023), p. 1-7
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Inappropriate prescribing is common in patients with end-stage kidney disease, especially in those over 65 years of age. Our study aimed to reveal potentially inappropriate drug prescribing in patients on peritoneal dialysis (PD) and explore factors associated with this phenomenon. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The research was designed as an observational, cross-sectional study on a convenient sample of 145 consecutive patients with PD who attended the four tertiary-care hospitals in Serbia. The main outcome was the extent of inappropriate prescribing, as assessed by the medication appropriateness index, and potential predictors were tested by multiple linear regression. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Inappropriate prescribing was a widespread phenomenon among patients on PD. The main factors that promote inappropriate prescribing in this subgroup of patients on kidney replacement therapy are comorbidities ( 〈 i 〉 p 〈 /i 〉 = 0.000), increased body weight ( 〈 i 〉 p 〈 /i 〉 = 0.022), a number of prescribed drugs ( 〈 i 〉 p 〈 /i 〉 = 0.000), and arterial hypertension on examination ( 〈 i 〉 p 〈 /i 〉 = 0.030). On the other hand, drinking alcohol and higher systolic blood pressure were associated with a lower inappropriate prescribing. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In order to prevent the occurrence of inappropriate prescribing and its severe health or economic consequences, clinicians should pay special attention when prescribing new drugs to high-risk patients.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000527263
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1483550-2
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  • 5
    Online Resource
    Online Resource
    THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS
    Polish Pharmaceutical Society ; 2019
    In:  Acta Poloniae Pharmaceutica - Drug Research Vol. 76, No. 1 ( 2019-2-28), p. 147-157
    Details
    In: Acta Poloniae Pharmaceutica - Drug Research, Polish Pharmaceutical Society, Vol. 76, No. 1 ( 2019-2-28), p. 147-157
    Type of Medium: Online Resource
    ISSN: 0001-6837
    URL: Article
    DOI: 10.32383/appdr/94079
    Language: Unknown
    Publisher: Polish Pharmaceutical Society
    Publication Date: 2019
    detail.hit.zdb_id: 2847632-3
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Vitamin B complex mitigates cardiac dysfunction in high‐methionine diet‐induced hyperhomocysteinemia
    Wiley ; 2018
    In:  Clinical and Experimental Pharmacology and Physiology Vol. 45, No. 7 ( 2018-07), p. 683-693
    Details
    In: Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 45, No. 7 ( 2018-07), p. 683-693
    Abstract: This research is designed to test the hypothesis that elevated homocysteine (Hcy) levels in vivo, caused by a deficit in vitamin B complex, promote changes in cardiac function and redox status that lead to heart failure. In order to conduct the study, we used adult male Wistar albino rats (n = 30; 4 weeks old; 100 ± 15 g body weight). Hyperhomocysteinaemia ( HH cy) in these animals was achieved by dietary manipulation. For 4 weeks, the animals were fed with a standard rodent chow (control, CF ), a diet enriched in methionine with no deficiency in B vitamins (i.e., folic acid, B6 and B12) ( HMNV ) or a diet enriched in methionine and deficient in B vitamins ( HMLV ). After 28 days of dietary manipulation, all animals were killed. The rat hearts were isolated and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure. We found a negative correlation between elevated serum Hcy and total body and heart weight. The maximum rate of left ventricular pressure development was significantly increased in the HMNV group compared with in the other groups. Systolic left ventricular pressure was significantly changed in all groups. HH cy induces remodelling of the cardiac tissues, as moderate HH cy is associated with more prominent interstitial and perivascular fibrosis. Our results suggest that a high methionine diet without vitamin B complex causes profound negative effects associated with HH cy.
    Type of Medium: Online Resource
    ISSN: 0305-1870 , 1440-1681
    URL: Issue
    URL: Article
    DOI: 10.1111/cep.2018.45.issue-7
    DOI: 10.1111/1440-1681.12930
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020033-X
    SSG: 15,3
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