In:
ChemMedChem, Wiley, Vol. 11, No. 4 ( 2016-02), p. 377-381
Abstract:
Neuromyelitis optica (NMO) is a demyelinating autoimmune disease of the optic nerve and spinal cord triggered by binding of NMO‐specific immunoglobulin G (NMO‐IgG) auto‐antibodies to the water channel aquaporin‐4 (AQP4) in astrocytes. To find potential NMO therapeutics, a screening system was established and used to identify inhibitors of NMO‐IgG‐mediated complement‐dependent cytotoxicity (CDC). The screening of approximately 400 compounds yielded potent hit compounds with inhibitory effects against CDC in U87‐MG cells expressing human AQP4. Derivatives of the hit compounds were synthesized and evaluated for their inhibition of CDC. Of the small molecules synthesized, ( E )‐1‐(2‐((4‐methoxyphenyl)sulfonyl)vinyl)‐[4‐[(3‐trifluoromethyl)phenyl] methoxy] benzene ( 5 c ) showed the most potent activity in both stably transfected U87‐MG cells and mice‐derived astrocytes. The results of this study suggest that 5 c , which targets NMO‐IgG‐specific CDC, may be useful as a research tool and a potential candidate for therapeutic development for the treatment of NMO.
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.201500546
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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