In:
Drug Metabolism and Personalized Therapy, Walter de Gruyter GmbH, Vol. 32, No. 4 ( 2017-12-20)
Abstract:
Fluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase ( Methods: Variants namely rs45445694, rs183205964, rs2853542 and rs151264360 of Results: The 2R/2R (rs45445694) was associated with clinical response (p=0.05, odds ratio (OR)=3.45) and severe toxicity (p=0.0014, OR=5.21, from pooled data). Expression analysis in tumor tissues suggested a correlation between the 2R/2R genotype and low Conclusions: The allele 2R (rs45445694) predicts severe toxicity and objective response in advanced CRC patients. In addition, the alleles G(rs2853542) and 6bp-(rs151264360) are independent predictors of response failure to chemotherapy. This is the first study made on a Latin American population that points out
Type of Medium:
Online Resource
ISSN:
2363-8915
,
2363-8907
DOI:
10.1515/dmpt-2017-0028
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2017
detail.hit.zdb_id:
2822040-7
detail.hit.zdb_id:
2820011-1
SSG:
15,3
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