In:
Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 28, No. 21 ( 2022-06), p. 1738-1744
Kurzfassung:
Mitochondria regulate a range of important physiological and biochemical cellular processes including
apoptotic cell death, energy production, calcium homeostasis, oxidative stress, and lipid metabolism. Given their role as the ‘engines’ of cells, their dysfunction is associated with a variety of disease states. Exploring the
relationship between mitochondrial function and disease can reveal the mechanism(s) of drug activity and disease pathology. In this review, we summarized the methods of evaluating the structure and function of mitochondria,
including the morphology, membrane fluidity, membrane potential, opening of the membrane permeability transition pore, inner membrane permeabilization, mitochondrial dynamics, mitophagy, oxidative stress,
energy metabolism-related enzymes, apoptotic pathway related proteins, calcium concentration, DNA copy number, oxygen consumption, β-oxidation-related genes and proteins, cardiolipin content, and adenosine triphosphate
content. We believe that the information presented in this review will help explore the pathological processes of mitochondria in the occurrence and development of diseases, as well as the activity and mechanism
of drugs, and the discovery of new drugs.
Materialart:
Online-Ressource
ISSN:
1381-6128
DOI:
10.2174/1381612828666220520161200
Sprache:
Englisch
Verlag:
Bentham Science Publishers Ltd.
Publikationsdatum:
2022
SSG:
15,3
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