GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Neuroprotective effects of Triticum aestivum L. against β‐Amyloid‐induced cell death and memory impairments
    Wiley ; 2010
    In:  Phytotherapy Research Vol. 24, No. 1 ( 2010-01), p. 76-84
    Details
    In: Phytotherapy Research, Wiley, Vol. 24, No. 1 ( 2010-01), p. 76-84
    Abstract: β‐Amyloid (Aβ) is a key component of senile plaques, neuropathological hallmarks of Alzheimer's disease (AD) and has been reported to induce cell death via oxidative stress. This study investigated the protective effects of Triticum aestivum L. (TAL) on Aβ‐induced apoptosis in SH‐SY5Y cells and cognitive dysfunctions in Sprague‐Dawley (SD) rats. Cells treated with Aβ exhibited decreased viability and apoptotic features, such as DNA fragmentation, alterations in mitochondria and an increased Bax/Bcl‐2 ratio, which were attenuated by TAL extract (TALE) pretreatment. To elucidate the neuroprotective mechanisms of TALE, the study examined Aβ‐induced oxidative stress and cellular defense. TALE pretreatment suppressed Aβ‐increased intracellular accumulation of reactive oxygen species (ROS) via up‐regulation of glutathione, an essential endogenous antioxidant. To further verify the effect of TALE on memory impairments, Aβ or scopolamine was injected in SD rats and a water maze task conducted as a spatial memory test. Aβ or scopolamine treatment increased the time taken to find the platform during training trials, which was decreased by TALE pretreatment. Furthermore, one of the active components of TALE, total dietary fiber also effectively inhibited Aβ‐induced cytotoxicity and scopolamine‐caused memory deficits. These results suggest that TALE may have preventive and/or therapeutic potential in the management of AD. Copyright © 2009 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v24:1
    DOI: 10.1002/ptr.2871
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1493490-5
    detail.hit.zdb_id: 639136-9
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Inhibition of UVB ‐Induced Skin Damage by Exopolymers from Aureobasidium pullulans SM‐2001 in Hairless Mice
    Wiley ; 2015
    In:  Basic & Clinical Pharmacology & Toxicology Vol. 116, No. 2 ( 2015-02), p. 73-86
    Details
    In: Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 116, No. 2 ( 2015-02), p. 73-86
    Abstract: Because antioxidants from natural sources may be an effective approach to the treatment and prevention of UV radiation‐induced skin damage, the effects of purified exopolymers from Aureobasidium pullulans SM‐2001 (‘E‐ AP ‐SM2001’) were evaluated in UVB ‐induced hairless mice. E‐ AP ‐SM2001 consists of 1.7% β‐1,3/1,6‐glucan, fibrous polysaccharides and other organic materials, such as amino acids, and mono‐ and di‐unsaturated fatty acids (linoleic and linolenic acids) and shows anti‐osteoporotic and immunomodulatory effects, through antioxidant and anti‐inflammatory mechanisms. Hairless mice were treated topically with vehicle, E‐ AP ‐SM2001 stock and two and four times diluted solutions once per day for 15 weeks against UVB irradiation (three times per week at 0.18 J/cm 2 ). The following parameters were evaluated in skin samples: myeloperoxidase ( MPO ) activity, cytokine levels [interleukin ( IL )‐1β and IL ‐10], endogenous antioxidant content (glutathione, GSH ), malondialdehyde ( MDA ) levels, superoxide anion production; matrix metalloproteases ( MMP ‐1, ‐9 and ‐13), GSH reductase and Nox2 (gp91phox) mRNA levels, and immunoreactivity for nitrotyrosine ( NT ), 4‐hydroxynonenal ( HNE ), caspase‐3, and cleaved poly( ADP ‐ribose) polymerase ( PARP ). Photoageing was induced by UVB irradiation through ROS ‐mediated inflammation, which was related to the depletion of endogenous antioxidants, activation of MMP s and keratinocyte apoptosis. Topical treatment with all three doses of E‐ AP ‐SM2001 and 5 n m myricetin attenuated the UV ‐induced depletion of GSH , activation of MMP s, production of IL ‐1β, the decrease in IL ‐10 and keratinocyte apoptosis. In this study, E‐ AP ‐SM2001 showed potent inhibitory effects against UVB ‐induced skin photoageing. Thus, E‐ AP ‐SM2001 may be useful as a functional ingredient in cosmetics, especially as a protective agent against UVB ‐induced skin photoageing.
    Type of Medium: Online Resource
    ISSN: 1742-7835 , 1742-7843
    URL: Issue
    URL: Article
    DOI: 10.1111/bcpt.2015.116.issue-2
    DOI: 10.1111/bcpt.12288
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2151592-X
    detail.hit.zdb_id: 2134679-3
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    High Platelet Reactivity Combined with CYP2C19 Genotype in Predicting Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention
    Wiley ; 2023
    In:  Clinical Pharmacology & Therapeutics Vol. 114, No. 5 ( 2023-11), p. 1104-1115
    Details
    In: Clinical Pharmacology & Therapeutics, Wiley, Vol. 114, No. 5 ( 2023-11), p. 1104-1115
    Abstract: Loss‐of‐function (LoF) alleles of cytochrome P450 2C19 ( CYP2C19 ), which are prevalent in East Asians, are linked to high platelet reactivity (HPR) phenotype and poor prognosis. We aimed to investigate the incremental predictive value of HPR combined with CYP2C19 genotype in predicting outcomes after drug‐eluting stent (DES) implantation. The patients treated with platelet function and genotype‐related long‐term prognosis in drug‐eluting stent (PTRG‐DES) consortium enrolled a total of 13,160 Korean patients treated with DES who had platelet function test (PFT) or CYP2C19 genotype, of which, 6,717 patients with PFT and genotype together were categorized. HPR was defined as VerifyNow ≥ 252 P2Y12 reaction unit. The primary outcome was the incidence of major adverse cardiac and cerebrovascular event (MACCE) 5 years after treatment. The patients with both HPR and CYP2C19 LoF/LoF had the highest MACCE rates (6.2%) and increased MACCE risk (adjusted hazard ratio: 1.89, 95% confidence interval: 1.20–2.91, P  = 0.006) compared with those without both HPR and CYP2C19 LoF/LoF. There was no effect of interaction between HPR and CYP2C19 genotype on the primary outcome ( P  = 0.424). Adding combined HPR and CYP2C19 genotype to the conventional model had an incremental influence in predicting MACCE and stent thrombosis. Compared to the model including HPR or CYP2C19 genotype alone, a combination model significantly improved the risk stratification for stent thrombosis but not MACCE. In DES‐treated East Asian patients, the combined evaluation of PFT results and CYP2C19 genotyping might improve risk prediction of ischemic events during clopidogrel treatment.
    Type of Medium: Online Resource
    ISSN: 0009-9236 , 1532-6535
    URL: Issue
    URL: Article
    DOI: 10.1002/cpt.v114.5
    DOI: 10.1002/cpt.3026
    RVK:
    XA 36900
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2040184-X
    detail.hit.zdb_id: 123793-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...