In:
Medicinal Research Reviews, Wiley, Vol. 42, No. 6 ( 2022-11), p. 2025-2066
Abstract:
Carbohydrate‐based drug discovery has gained more and more attention during the last few decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in plants of the family Convolvulaceae. Over the last decade, a number of natural resin glycosides and derivatives have been isolated and identified, and exhibited a broad spectrum of biological activities, such as cytotoxic, multidrug‐resistant reversal on both microbial pathogens and mammalian cancer cells, antivirus, anticonvulsant, antidepressant, sedative, vasorelaxant, laxative, and α‐glucosidase inhibitory effects, indicating their potential as lead compounds for drug discovery. A systematic review of the literature studies was carried out to summarize the chemistry and biological activity of resin glycosides from Convolvulaceae species, based on various data sources such as PubMed, Web of Science, Scopus, and Google scholar. The keyword “Convolvulaceae” was paired with “resin glycoside,” “glycosidic acid,” “glycolipid,” or “oligosaccharide,” and the references published between 2009 and June 2021 were covered. In this article, we comprehensively reviewed the structures of 288 natural resin glycoside and derivatives newly reported in the last decade. Moreover, we summarized the biological activities and mechanisms of action of the resin glycosides with pharmaceutical potential. Taken together, great progress has been made on the chemistry and biological activity of resin glycosides from Convolvulaceae species, however, more exploratory research is still needed, especially on the mechanism of action of the biological activities.
Type of Medium:
Online Resource
ISSN:
0198-6325
,
1098-1128
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2001841-1
SSG:
15,3
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