In:
Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 121, No. S3 ( 2017-09), p. 23-29
Abstract:
Changes in paradigm contribute to advances in research. The current paradigms for the evaluation of toxicity of chemicals refer to linear or curvilinear dose–response curves with or without threshold and to surface‐dependent induction of oxidative damage for particles. The unique physicochemical properties and biological/genotoxic activity of engineered nanomaterials ( NM s) require the development of a new paradigm. Because of their unusual dosimetry and their multiple interactions at NM level (agglomeration/aggregation) and at different cellular and extracellular levels, NM s are likely to have complex modes of action (multiple hits at multiple targets) leading to complex thresholded–non‐thresholded dose–response curves. Understanding their cellular targets and their modes of action will contribute to the production of safe‐by‐design NM s. An integrative, cell‐by‐cell approach for genotoxic effects should be applied to tackle this emerging paradigm in nano‐genotoxicology.
Type of Medium:
Online Resource
ISSN:
1742-7835
,
1742-7843
DOI:
10.1111/bcpt.2017.121.issue-S3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2151592-X
detail.hit.zdb_id:
2134679-3
SSG:
15,3
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