In:
ChemMedChem, Wiley, Vol. 2, No. 9 ( 2007-09-10), p. 1361-1369
Abstract:
Three series of metronidazole–flavonoid derivatives were generated and evaluated for antimicrobial activity against H. pylori . Among these compounds, high anti‐ H. pylori activities were observed in isoflavones derivatives 4 – 7 , 19 , and 20 but exhibited no inhibitory activity against other sorts of bacteria and fungi, for example, Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence , and Aspergillus niger . Genistein derivative 6 with the potent activity (MIC=0.39 μg mL −1 ) was 〉 50‐fold more than metronidazole, and comparable to the positive control amoxicillin. Additionally, compound 6 can significantly attenuate the increase in interleukin‐8 (IL‐8) levels in the AGS cells stimulated by H. pylori water extract (HPE) at concentrations of 15, 30, and 60 μmol L −1 , which did not show any effects on the cell viability.
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.200700097
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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