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  • SAGE Publications  (9)
  • Pharmacy  (9)
  • 1
    Online Resource
    Online Resource
    The Short Hairpin RNA Driven by Polymerase II Suppresses both Wild-Type and Lamivudine-Resistant Hepatitis B Virus Strains
    SAGE Publications ; 2007
    In:  Antiviral Therapy Vol. 12, No. 6 ( 2007-08), p. 865-876
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 12, No. 6 ( 2007-08), p. 865-876
    Abstract: Chronic infection with hepatitis B virus (HBV) is widespread because of the limited availability of therapeutic treatments. Although previous reports have suggested that RNA interference has promise as a treatment for HBV infection, further studies of long-term and off-target drug effects on HBV, especially on drug-resistant strains of HBV, are needed. Therefore, seven vectors that express short hairpin RNAs (shRNAs), driven by the polymerase II promoter, pSilencer4.1/HBV, were constructed to target open reading frames (ORFs) of the HBV C and S genes from wild-type and drug-resistant strains. Treatment efficiency was also assessed. Methods The pSilencer4.1/HBV vectors were investigated in HepG2.2.15 cells and transgenic mice that consistently produce wild-type HBV. Additionally, vectors that produce a lamivudine-resistant strain of HBV were developed and cotransfected, along with pSilencer/HBV, into both HepG2 cells and mice. The effects of polymerase-II-driven pSilencer4.1/HBV were compared with those of polymerase-III-driven pSilencer3.1/HBV at both the gene and protein level. Results pSilencer4.1/HBV inhibited the expression of viral protein, DNA and HBV subtype ayw mRNA in both HepG2.2.15 cells and transgenic mice. Toxicity, as well as off-target effects, did not occur after a short- to medium-term examination. Moreover, an HBV strain resistant to lamivudine, subtype adr, was suppressed by shRNA in both HepG2 cells and mice. In contrast to polymerase III, vectors that used polymerase II could drive efficient silencing without off-target effects. Conclusions Silencing by shRNA dramatically inhibited HBV expression and replication regardless of strain type. ShRNA could therefore be a promising treatment for HBV infection.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350701200607
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2118396-X
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  • 2
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    Online Resource
    A Survey of the Chemical Compounds of Piper spp. (Piperaceae) and Their Biological Activities
    SAGE Publications ; 2016
    In:  Natural Product Communications Vol. 11, No. 9 ( 2016-09), p. 1934578X1601100-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 11, No. 9 ( 2016-09), p. 1934578X1601100-
    Abstract: The genus Piper is one of the largest genera in the Piperaceae, with most species widely distributed globally, covering all continents. To date, many Piper species have been scientifically investigated for their chemical diversities and interesting broad spectrum of bioactivities, including central nervous system (CNS), pesticidal, antifungal and antibacterial effects. This review systematically summarizes the scaffolds of the alkaloids reported, the major chemicals isolated from Piper spp., and their biological activities. Besides the alkaloids, some neolignans with rearranged skeletons show structural diversities, while the chalcones, flavonoids and kava-pyrones have some potential activities. Herein, the sesquiterpenes and phenolic compounds from Piper species and their bioactivities are also surveyed.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1601100948
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2430442-6
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  • 3
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    Online Resource
    New Phenylpropanoid-Substituted Flavan-3-ols from Pu-er Ripe Tea
    SAGE Publications ; 2014
    In:  Natural Product Communications Vol. 9, No. 8 ( 2014-08), p. 1934578X1400900-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 9, No. 8 ( 2014-08), p. 1934578X1400900-
    Abstract: Pu-er ripe tea is a special microbial post-fermented tea made from Pu-er raw tea, a kind of green tea produced from the leaves of Camellia sinensis var. assamica. It is one of the most consumed teas in the past two decades in China, due to its special flavor, taste, and beneficial effects. This work aimed to obtain diverse catechin structures from Pu-er ripe tea, which led to the isolation of four new phenylpropanoid-substituted flavan-3-ols, puerins C-F (1-4), together with four known flavan-3-ols, (+)-catechin (5), (-)-epicatechin (6), (±)-gallocatechin (7), and (-)-epigallocatechin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR, mass and CD spectra. Compounds 1-4, which could be formed in the post-fermentative process of Pu-er tea, were isolated for the first time from tea and Theaceae plant.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1400900827
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
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  • 4
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    Online Resource
    Sense Ginsenosides From Ginsengs: Structure-Activity Relationship in Autophagy
    SAGE Publications ; 2019
    In:  Natural Product Communications Vol. 14, No. 6 ( 2019-06), p. 1934578X1985822-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 14, No. 6 ( 2019-06), p. 1934578X1985822-
    Abstract: The term ginseng refers to the dried roots of several plants belonging to the genus Panax of the Araliaceae family. The 3 major commercial ginsengs are Panax notoginseng (Burk.) F.H. Chen (Notoginseng), P. ginseng C.A. Meyer (Ginseng), and P. quinquefolius L. (American ginseng), which have been used as herbal medicines. Over 18,000 papers on ginsengs have been published on the basis of their structural diversity and biological activities. Many reviews have summarized the phytochemistry, pharmacology, and clinical use of ginsengs, but the structure-activity relationship (SAR) of ginsenosides from ginsengs in autophagy is unavailable. Herein, we review the structural diversity of ginsenosides, especially the ones in notoginseng, and the SAR in autophagic activity is discussed in detail.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X19858223
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 5
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    Online Resource
    Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis
    SAGE Publications ; 2016
    In:  Natural Product Communications Vol. 11, No. 6 ( 2016-06), p. 1934578X1601100-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 11, No. 6 ( 2016-06), p. 1934578X1601100-
    Abstract: Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3—18). Their structures were elucidated on the basis of detailed spectroscopic, including ID and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC 50 value of 18.1 μM, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC 50 values of 34.4 and 32.8 μM, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 μM at 10 μM concentration.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1601100607
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 6
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    Online Resource
    Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis
    SAGE Publications ; 2023
    In:  Pharmacognosy Magazine
    Details
    In: Pharmacognosy Magazine, SAGE Publications
    Abstract: Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, antibacterial, and anticancer effects. Objectives Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis. Materials and Methods After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins. Results The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22. Conclusion GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.
    Type of Medium: Online Resource
    ISSN: 0973-1296 , 0976-4062
    URL: Article
    DOI: 10.1177/09731296231198931
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2274976-7
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  • 7
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    Online Resource
    Nobiletin Inhibits Cell Growth, Migration and Invasion, and Enhances the Anti-Cancer Effect of Gemcitabine on Pancreatic Cancer Cells
    SAGE Publications ; 2021
    In:  Natural Product Communications Vol. 16, No. 4 ( 2021-04), p. 1934578X2110040-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 16, No. 4 ( 2021-04), p. 1934578X2110040-
    Abstract: Natural products are very promising adjuvants with a variety of biological activities. Nobiletin, a citrus polymethoxyflavone, has been shown to exert an anticancer effect in various cell lines. In this study, we investigated the effects of nobiletin on cell viability, sphere formation, migration and invasion of pancreatic cancer cells, and the underlying mechanisms. Our results demonstrate that nobiletin significantly inhibited PANC-1 cell migration and invasion, and these effects were associated with downregulation of MMP-2. We also found that nobiletin, in a low concentration, exhibited a strong inhibitory effect on sphere formation. The potential molecular mechanisms were related to significant downregulation of p-mTOR and p-STAT3. Furthermore, we found that nobiletin combined with gemcitabine synergistically inhibited PANC-1 cell viability and sphere formation. The underlying mechanisms of the synergistic inhibition on growth were associated with decreases in p-STAT3 expression. Overall, our results suggest that nobiletin may be a promising candidate for pancreatic cancer adjuvant treatment.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X211004062
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 8
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    Online Resource
    Iridoid glycosides from the Genus Gentiana (Gentianaceae) and their Chemotaxonomic Sense
    SAGE Publications ; 2017
    In:  Natural Product Communications Vol. 12, No. 10 ( 2017-10), p. 1934578X1701201-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 12, No. 10 ( 2017-10), p. 1934578X1701201-
    Abstract: The genus Gentiana is one of the largest genera in the Gentianaceae family. Many Gentiana species have been scientifically investigated for their chemical constituents and chemotaxonomic sense. To date, more than 500 chemical compounds were isolated from Gentiana plant. Several researchers have reviewed the secondary metabolites and their bioactivities of Gentiana plants. However, a survey on iridoid glycosides and their chemotaxonomic sense of the genus Gentiana are unavailable. Iridoid glycosides are the major chemicals isolated from Gentiana spp., which serve as potential chemotaxonomic markers to differentiate Gentiana species. Herein, the review systematically summarizes the scaffolds of the iridoids reported according to the biosynthetic pathway of natural iridoid glycosides. Furthermore, the taxonomy of Gentiana and chemotaxonomic sense of iridoid glycosides in the genus Gentiana were surveyed.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1701201035
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2430442-6
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  • 9
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    Online Resource
    Penichrypyrone A: A New γ-Pyrone Derivative from the Sponge-Derived Fungus Penicillium chrysogenum LS18
    SAGE Publications ; 2019
    In:  Natural Product Communications Vol. 14, No. 6 ( 2019-06), p. 1934578X1986037-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 14, No. 6 ( 2019-06), p. 1934578X1986037-
    Abstract: A new γ-pyrone derivative, penichrypyrone A (1), along with 4 known compounds, conichaetone E (2), janthinone (3), mrlactonel (4), and aspergillusene A (5), was isolated from the EtOAc extract of the sponge-derived fungus Penicillium chrysogenum LS18. Their structures were elucidated on the basis of the detailed spectroscopic analysis and comparison with the literature data. All the isolated compounds were evaluated for their antioxidant activity.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X19860378
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2430442-6
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