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  • SAGE Publications  (35)
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  • 1
    Online Resource
    Online Resource
    Anti-Photoaging Effects of the Ethanol Extract from Eucommia ulmoides Oliv. Seed Meal on UVB-irradiated HaCaT Cells and Mice
    SAGE Publications ; 2023
    In:  Pharmacognosy Magazine Vol. 19, No. 3 ( 2023-09), p. 603-614
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 19, No. 3 ( 2023-09), p. 603-614
    Abstract: Eucommia ulmoides Oliv. is a traditional Chinese medicine, and its flowers, leaves, and seeds are widely used as food. Currently, E. ulmoides seed oil is capable of improving glucose and lipid metabolism in type 2 diabetic mice, but E. ulmoides seed meal is not fully utilized, and the anti-photoaging effect of it is still unclear. Objectives We examined the anti-photoaging effect of the ethanol extracts of E. ulmoides seed meal (EUSM) in UVB-stimulated HaCaT cells and mice. Materials and Methods EUSM was analyzed using Q-Orbitrap-based high-resolution LC-MS/MS. In vivo and in vitro experiments were conducted using normal mice and HaCaT cells, respectively. Hematoxylin and eosin (H & E) staining and Masson’s staining were used to evaluate epidermal thickness and degree of skin fibrosis. The production of hyaluronic acid (HA) and total protein using ELISA kits. The expression of levels for collagen type I α 1 (COL1A1), hyaluronidase-1 (HYAL-1), MMP-3, and MMP-9 were assessed using semi-quantitative real-time polymerase chain reaction (qRT-PCR). Results EUSM contains all-trans-retinoic acid, medicagenic acid, and other chemical constituents. EUSM increased the level of total collagen by reducing matrix metalloproteinase expression, and it enhanced the content of HA. In addition, EUSM reduced the production of wrinkles in UVB-induced mouse skin and showed that EUSM decreased the level of malondialdehyde (MDA) and increased the contents of superoxide dismutase (SOD) and catalase (CAT) in the mouse skin tissue. Conclusion EUSM has therapeutic potential for UVB-induced skin photoaging and provided a rationale for the application of EUSM in the cosmetic field.
    Type of Medium: Online Resource
    ISSN: 0973-1296 , 0976-4062
    URL: Article
    DOI: 10.1177/09731296231170932
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2274976-7
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  • 2
    Online Resource
    Online Resource
    Factors Associated with Serum Hepatitis B Surface Antigen Levels and Its On-Treatment Changes in Patients under Lamivudine Therapy
    SAGE Publications ; 2012
    In:  Antiviral Therapy Vol. 17, No. 1 ( 2012-01), p. 71-79
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 17, No. 1 ( 2012-01), p. 71-79
    Abstract: We aimed to investigate factors associated with serum hepatitis B surface antigen (HBsAg) levels and its kinetics under lamivudine treatment in chronic hepatitis B patients. Methods HBsAg levels were measured with the Architect HBsAg assay (Abbott laboratories, Abbott Park, IL, USA) in genotype B (HBV/B) or C (HBV/C) patients ( n=218). Early HBsAg kinetics in 86 hepatitis B e antigen (HBeAg)- positive patients and long-term HBsAg changes in 45 patients with rapid and sustained viral suppression were further analysed. Results Mean HBsAg levels were higher in male ( n=181) than in female ( n=37) patients (3.59 versus 3.23 log 10 IU/ ml; P=0.036), and higher in 121 HBV/B than in 97 HBV/C patients (3.68 versus 3.34 log 10 IU/ml; P=0.006). In addition to HBV DNA loads ( P 〈 0.001), male gender ( P=0.012) and HBV/B infection ( P=0.035) were independently associated with higher HBsAg levels in antiviral-naive patients. HBsAg increases (0.00–0.87 log 10 ) were found in 28/86 patients who obtained viral suppression under 12 weeks of lamivudine therapy. Higher baseline HBsAg levels ( P=0.046), HBV/B infection ( P=0.007) and faster HBV DNA declines ( P=0.006) independently contributed to greater HBsAg decreases under 12 weeks treatment. An apparent dissociation between HBsAg and HBV DNA changes were found in 14/45 patients with rapid and sustained viral suppression, who had low baseline HBsAg levels and predominant HBV/C infection. Conclusions HBV/B and male gender were associated with higher HBsAg levels in antiviral-naive patients. Higher baseline HBsAg levels and HBV/B infection contributed to greater early HBsAg declines in HBeAg-positive patients, and might correlate with discordance between HBsAg and HBeAg or HBV DNA under long-term lamivudine treatment.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1925
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2118396-X
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  • 3
    Online Resource
    Online Resource
    Inhibitory Effects of Indigowoad Root Polysaccharides on Porcine Reproductive and Respiratory Syndrome Virus Replication In Vitro
    SAGE Publications ; 2011
    In:  Antiviral Therapy Vol. 16, No. 3 ( 2011-04), p. 357-363
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 16, No. 3 ( 2011-04), p. 357-363
    Abstract: Indigowoad root polysaccharide (IRPS) is a natural polysaccharide isolated from the traditional Chinese medicinal herb Radix Isatidis, and has many kinds of biological activities. However, the IRPS antiviral activity, especially the anti-porcine reproductive and respiratory syndrome virus (PRRSV) effect, has not been evaluated. Methods PRRSV was propagated in the MARC-145 cell line, and viral titre was determined by cytopathic effect and expressed as the 50% tissue culture infection dose (TCID 50 ) in the current study. The cell cytotoxic effect of IRPS toward MARC-145 was evaluated by MTT assay firstly, then the inhibitory effects of IRPS on PRRSV replication in vitro were investigated by determining the effect of IRPS upon a single replicative cycle of PRRSV in MARC- 145 cells. The effects of IRPS on viral RNA and protein synthesis in PRRSV-infected cells were investigated using real-time PCR and double-antibody (sandwich) ELISA. Results IRPS was able to effectively suppress the infectivity of the PRRSV in a dose-dependent manner, especially by adding IRPS during the PRRSV infection. IRPS could affect the attachment of PRRSV to MARC-145 cells, and also inhibit the viral RNA and protein synthesis. Conclusions IRPS has an antiviral effect on PRRSV replication in MARC-145 cells and might be useful in medical development for antiviral research. However, the precise mechanism of the host and viral targets of IRPS are unknown, so further studies should be conducted to investigate the precise mechanism of IRPS inhibitory effect on PRRSV infection.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1755
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
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  • 4
    Online Resource
    Online Resource
    Jiedu Huoxue Decoction for Cytokine Storm and Thrombosis in Severe COVID-19: A Combined Bioinformatics and Computational Chemistry Approach
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 4 ( 2022-04), p. 1934578X2210969-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 4 ( 2022-04), p. 1934578X2210969-
    Abstract: Jiedu Huoxue Decoction (JHD), a recommended traditional prescription for patients with severe COVID-19, has appeared in the treatment protocols in China. Based on bioinformatics and computational chemistry methods, including molecular docking, molecular dynamics (MD) simulation, and Molecular Mechanics Generalized Born Surface Area (MM/GBSA) calculation, we aimed to reveal the mechanism of JHD in treating severe COVID-19. The compounds in JHD were obtained and screened on TCMSP, SwissADME, and ADMETLab platforms. The compound targets were obtained from TCMSP and STITCH, while COVID-19 targets were obtained from Genecards and NCBI. The protein-protein interaction network was constructed by using STRING. Gene Ontology (GO) and KEGG enrichment were performed with ClueGO and R language. AutoDock vina was employed for molecular docking. 100 ns MD simulation of the optimal docking complex was carried out with AmberTools 20. A total of 84 compounds and 29 potential targets of JHD for COVID-19 were collected. The key phytochemicals included quercetin, luteolin, β-sitosterol, puerarin, stigmasterol, kaempferol, and wogonin, which could regulate the immune system. The hub genes included IL6, IL10, VEGFA, IL1B, CCL2, HMOX1, DPP4, and ACE2. ACE2 and DPP4 were related to SARS-CoV-2 entering cells. GO and KEGG analysis showed that JHD could intervene in cytokine storm and endothelial proliferation and migration related to thrombosis. The molecular docking, 100 ns MD simulation, and MM/GBSA calculation confirmed that targets enriched in the COVID-19 pathway had high affinities with related compounds, and the conformations of the puerarin-ACE2, quercetin-EGFR, luteolin-EGFR, and quercetin-IL1B complexes were stable. In a word, JHD could treat COVID-19 by intervening in cytokine storm, thrombosis, and the entry of SARS-CoV-2, while regulating the immune system. These mechanisms were consistent with JHD's therapeutic concept of “detoxification” and “promoting blood circulation and removing blood stasis” in treating COVID-19. The research provides a theoretical basis for the development and application of JHD.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221096966
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Pestalotilide A, a New Cytotoxic Diphenyl Ether Derivative from Pestalotiposis guepinii
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 6 ( 2018-06), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 6 ( 2018-06), p. 1934578X1801300-
    Abstract: A new diphenyl ether derivative, named pestalotilide A (1), along with four known compounds (2-5) have been isolated from the organic extracts of an endophytic fungus Pestalotiposis guepinii. Their structures were elucidated on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic data analyses. These isolates were evaluated for cytotoxicity against three cancer cell lines: Hela, HCT116 and A549; pestalotilide A exhibited weak in vitro anti-proliferative activities against the tested cell lines, with IC 50 values of 23.8, 18.4 and 35.2 μM, respectively.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300621
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 6
    Online Resource
    Online Resource
    Two Cosmetic Properties of an Ethanol Extract of a Cultured and Edible Red Macroalga, Bangia fuscopurpurea : Moisturizing and Whitening Effects
    SAGE Publications ; 2020
    In:  Natural Product Communications Vol. 15, No. 8 ( 2020-08), p. 1934578X2094466-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 15, No. 8 ( 2020-08), p. 1934578X2094466-
    Abstract: Previous studies have focused on the role of a cultured red macroalga Bangia fuscopurpurea as a functional food; however, except for antioxidant activity, there are no reports directly regarding the potential cosmetic properties of this alga. Our present study explored the moisturizing effect of its ethanol extract (BFH1) and used the tyrosinase activity inhibition assay to evaluate its in vitro whitening effect. The in vitro moisture-retention ability of BFH1 was similar to that of glycerol (positive control), but its moisture-absorption ability was significantly higher. The overall in vivo moisturizing effect of topical application of BFH1 in mice was similar to that of glycerol, but BFH1 did not cause significant changes in the oil content of the skin, and there were no obvious side effects regarding skin appearance and external behavior during treatment. BFH1 exerted in vitro tyrosinase inhibitory activity with a half-maximal inhibitory concentration (IC 50 ) of 48.3 μg/mL (IC 50 of positive control, vitamin C: 19.6 μg/mL). The total phenolic content of BFH1 was determined as 10.8 % ± 0.07 %. Thus, BFH1 has high potential to be turned into a cosmetic ingredient with moisturizing and whitening effects.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X20944668
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Cembranoids From the Leaves of Nicotiana tabacum and Their Neuroprotective Activities
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 4 ( 2022-04), p. 1934578X2210941-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 4 ( 2022-04), p. 1934578X2210941-
    Abstract: A new cembrane-type diterpenoid (1) and 9 known cembranoids (2-10) were isolated from the leaves of Nicotiana tabacum. The structure of the new metabolite was confirmed by extensive analyses of their spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D- and 2D nuclear magnetic resonance (NMR) spectroscopy, and infrared spectroscopy (IR). All of the isolated compounds were tested for their protective effects against oxygen-glucose deprivation (OGD)-induced neurotoxicity in SH-SY5Y cells. The new compound 1 exhibited a moderate protective effect against OGD-induced neurotoxicity at 10 μM.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221094107
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    Proliferative Constituents from the Leaves of Micromelum integerrimum
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 10 ( 2015-10), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 10 ( 2015-10), p. 1934578X1501001-
    Abstract: wo new compounds, 5- O-methyl-4-desmethyl-myricanol (1) and 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (2), were isolated from the leaves of Micromelum integerrimum. Their structures were determined by spectroscopic methods. Additionally, compound 1 could stimulate the growth of NIH3T3 cells and promote cell migration. Compound 1 might exert its effects through increasing the protein expression of connective tissue growth factor.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001020
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 9
    Online Resource
    Online Resource
    Chemical Composition, Antioxidant, Antimicrobial and Anti-inflammatory Activities of the Stem and Leaf Essential Oils from Piper flaviflorum from Xishuangbanna, SW China
    SAGE Publications ; 2014
    In:  Natural Product Communications Vol. 9, No. 7 ( 2014-07), p. 1934578X1400900-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 9, No. 7 ( 2014-07), p. 1934578X1400900-
    Abstract: The present study is the first investigation of the chemical composition, antioxidant, antimicrobial and anti-inflammatory activities of the stem and leaf essential oils from Piper flaviflorum C.DC (SEOP and LEOP), a plant that has been consumed as a wild vegetable, and used as medicine, and spice by the ethnic groups in Xishuangbanna, SW China. Analyzed by GC-MS, 42 and 30 components were identified representing 90.1% and 95.3% of the SEOP and LEOP, with (E)-nerolidol (16.7% and 40.5%), β-caryophyllene (26.6% and 14.6%) and elixene (5.3% and 12.3%) as their main constituents, respectively. Our results indicate that SEOP and LEOP have good anti-inflammatory activity by significantly inhibiting NO production induced by LPS in RAW 264.7 cells at 0.04± without effect on cell viability, and negligible antioxidant activity in both ABTS and FRAP assays. Moreover, the LEOP showed comparable activity with the positive control (tigecycline) against Aspergillus fumigatus, with MIC and MBC values ranging from 256 to 1024 μg/mL. The anti-inflammatory activity in LPS-induced RAW 264.7 cells is worthy of further investigation to discover the possible mechanisms of the NO production inhibition effect of these essential oils.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1400900732
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
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  • 10
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    Online Resource
    Triterpenoid Saponins from the Roots of Glycyrrhiza Glabra
    SAGE Publications ; 2019
    In:  Natural Product Communications Vol. 14, No. 1 ( 2019-01), p. 1934578X1901400-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 14, No. 1 ( 2019-01), p. 1934578X1901400-
    Abstract: Seven new oleanane-type triterpenoid saponins (glabasaponin A-G) were isolated from the roots of Glycyrrhiza glabra together with a known compound macedonoside A. The structures of compounds 1-7 were determined on the basis of 1D and 2D NMR as well as the MS data analyses. The sugar moieties of compound 5 were confirmed by gas chromatography after hydrolysis.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1901400106
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2430442-6
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