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  • SAGE Publications  (4)
  • Pharmacy  (4)
  • 1
    Online Resource
    Online Resource
    Randomized Study of Asunaprevir plus Pegylated Interferon-α and Ribavirin for Previously Untreated Genotype 1 Chronic Hepatitis C
    SAGE Publications ; 2013
    In:  Antiviral Therapy Vol. 18, No. 7 ( 2013-10), p. 885-893
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 18, No. 7 ( 2013-10), p. 885-893
    Abstract: Asunaprevir is a selective NS3 protease inhibitor with in vitro activity against HCV genotypes 1 and 4. Methods In this Phase IIa double-blind study, treatment-naive HCV genotype-1-infected patients in the United States and France were randomly assigned 1:1:1:1 to placebo or asunaprevir 200 mg twice daily, 600 mg twice daily or 600 mg once daily in combination with pegylated interferon (PEG-IFN)-α2a and ribavirin for 48 weeks. The primary efficacy end point was undetectable HCV RNA at weeks 4 and 12 (extended rapid virological response [eRVR]). Other end points included safety and undetectable HCV RNA at 24 weeks post-treatment (24-week sustained virological response [SVR 24 ]). Results A total of 47 patients were randomized and treated. eRVR was achieved by 75% (9/12), 75% (9/12) and 92% (11/12) of patients in the asunaprevir 200 mg twice-daily, 600 mg twice-daily and 600 mg once-daily groups, respectively, versus 0% (0/11) in the placebo group. Corresponding SVR 24 rates were 83% (10/12), 83% (10/12) and 92% (11/12) in the asunaprevir groups and 46% (5/11) in the placebo group. There was no virological breakthrough in any asunaprevir group. Following the 12-week analysis, the 600 mg doses were reduced to 200 mg twice daily because of a greater frequency of transaminase elevations at the 600 mg dose. The most common grade 3–4 laboratory abnormalities were consistent with those reported for PEG-IFN and ribavirin. Conclusions Asunaprevir plus PEG-IFN and ribavirin achieved higher response rates than placebo plus PEG-IFN and ribavirin, with a tolerable adverse event profile at the 200 mg twice-daily dose. This dose is being evaluated in the Phase IIb and Phase III studies.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP2660
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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    Online Resource
  • 2
    Online Resource
    Online Resource
    A Survey of Arizona Pharmacists to Identify Opportunities to Enhance Pharmacists’ Competitiveness in a Tightening Labor Market
    SAGE Publications ; 2022
    In:  Journal of Pharmacy Practice Vol. 35, No. 4 ( 2022-08), p. 617-625
    Details
    In: Journal of Pharmacy Practice, SAGE Publications, Vol. 35, No. 4 ( 2022-08), p. 617-625
    Abstract: The pharmacy profession has experienced dramatic shifts in scopes of practice, services offered, and employment opportunities over the last couple decades. At the same time, the number of students graduating from pharmacy school each year has steadily increased. The combined effect of these factors is a tightening labor market. Identification of potential knowledge and skill deficits in the applicant pool will create opportunity for pharmacists to tailor their personal development and educators to design content to address contemporary needs. Objective: To determine if the current pharmacist pool meets employment needs in Arizona with respect to specific skills and knowledge. Methods: In a cross-sectional survey design, Arizona licensed pharmacists were asked to provide their perspective of the knowledge and skills of candidates for pharmacist positions within 8 skill & knowledge domains. Descriptive statistics were used for respondents’ characteristics. A multivariate logistic regression was used for association between respondent characteristics and responses. Free responses were assessed using a qualitative thematic analysis. Results: Among 685 respondents, 88% were employed, 48% had precepting experience, and 44% were involved with hiring. The majority were from chain community pharmacies (33%) and inpatient settings (22%). Management and conflict resolution skills were reported as lacking by 35% and 28% of respondents respectively; 24% reported insufficient compounding knowledge. Conclusion: Our findings suggest knowledge deficits in management, conflict resolution, and compounding. This information can be used for career planning and for educational program development or curricular enhancements. Similar studies in other regions will provide data on national needs.
    Type of Medium: Online Resource
    ISSN: 0897-1900 , 1531-1937
    URL: Article
    DOI: 10.1177/08971900211000708
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2131091-9
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Therapeutic Options for the SARS-CoV-2 Virus: Is There a Key in Herbal Medicine?
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 9 ( 2022-09), p. 1934578X2211263-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 9 ( 2022-09), p. 1934578X2211263-
    Abstract: SARS-CoV-2 has been responsible for over 500 million cumulative cases all over the world since December 2019 and has marked the third introduction of a highly pathogenic virus after SARS-CoV and MERS-CoV. This virus is in a winning situation because scientists are still racing to explore effective therapeutics, vaccines, and event treatment regimens. In view of progress in current disease management, until now none of the preventive/treatment measures can be considered entirely effective to treat SARS-CoV-2 infection. Therefore, it is required to look up substitute ways for the management of this disease. In this context, herbal medicines could be a good choice. This article emphasizes the antiviral potential of some herbal constituents which further can be a drug of choice in SARS-CoV-2 treatment. This article may be a ready reference for discovering natural lead compounds and targets in SARS-CoV-2 associated works.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221126303
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2430442-6
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  • 4
    Online Resource
    Online Resource
    A Cross-Sectional Survey Study of Student Pharmacists’ Career Interests
    SAGE Publications ; 2023
    In:  Journal of Pharmacy Practice
    Details
    In: Journal of Pharmacy Practice, SAGE Publications
    Abstract: Background: Career planning is important to student pharmacists and pharmacy schools due to slower job growth for pharmacists over the last decade. Understanding students’ career interests can help colleges and schools of pharmacy develop targeted career planning, as well as meaningful curricular and co-curricular activities. Objectives: This study aims to describe the career path interests of two doctor of pharmacy cohorts in each professional year (P1 through P4) during the 2019-2020 and 2020-2021 academic years. Methods: This was a retrospective cross-sectional survey study conducted at an Accreditation Council for Pharmacy Education accredited college of pharmacy in the United States. Students were surveyed regarding their career interests in a mentorship program. Using frequencies and proportions we reported the pattern of students’ career interests. Results: The top careers most frequently selected by students in the 2019-2020 cohort as their first choice were hospital (21.4% of P1s, 17.4% of P3s) and community (24.6% of P2s, 24.3% of P4s). Those career paths for the 2020-2021 cohort were hospital (21.4% of P1s), clinical specialty (19.2% of P2s, 21.9% of P4s), and community (22.9% of P3s). In both cohorts and all professional program years, students selected a broad range of first choice career interests and even broader range when indicating top 3 careers of interest. Conclusion: Overall, the most frequently selected career path interests were hospital, community, clinical specialty, and ambulatory care. However, there was broad variability in the career interests, accounting for a third to half of the students with interests different than the majority.
    Type of Medium: Online Resource
    ISSN: 0897-1900 , 1531-1937
    URL: Article
    DOI: 10.1177/08971900231198926
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2131091-9
    SSG: 15,3
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