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  • S. Karger AG  (5)
  • Pharmacy  (5)
  • 1
    Online Resource
    Online Resource
    Effects of a Multidomain Lifestyle Modification on Cognitive Function in Older Adults: An Eighteen-Month Community-Based Cluster Randomized Controlled Trial
    S. Karger AG ; 2014
    In:  Psychotherapy and Psychosomatics Vol. 83, No. 5 ( 2014), p. 270-278
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 83, No. 5 ( 2014), p. 270-278
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 A healthy lifestyle may protect against cognitive decline. We examined outcomes in elderly individuals after 18 months of a five-group intervention program consisting of various modalities to prevent cognitive decline. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We conducted a cluster randomized controlled trial assessing 460 community-dwelling individuals aged 60 years and older in a geriatric community mental health center in Suwon, Republic of Korea, between 2008 and 2010. We developed an intervention program based on the principles of contingency management, which could be delivered by ordinary primary health workers. Group A (n = 81) received standard care services. Group B (n = 80) received bimonthly (once every 2 months) telephonic care management. Group C (n = 111) received monthly telephonic care management and educational materials similar to those in group B. Group D (n = 93) received bimonthly health worker-initiated visits and counseling. Group E (n = 94) received bimonthly health worker-initiated visits, counseling, and rewards for adherence to the program. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The primary outcome was the change in Mini-Mental State Examination (MMSE) scores from baseline to the final follow-up visit at 18 months. Group E showed superior cognitive function to group A (adjusted coefficient β = 0.99, p = 0.044), with participation in cognitive activities being the most important determining factor among several health behaviors (adjusted coefficient β = 1.04, p 〈 0.01). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Engaging in cognitive activities, in combination with positive health behaviors, may be most beneficial in preserving cognitive abilities in community-dwelling older adults.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000360820
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1472321-9
    detail.hit.zdb_id: 209490-3
    SSG: 5,2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial
    S. Karger AG ; 2016
    In:  Psychotherapy and Psychosomatics Vol. 85, No. 4 ( 2016), p. 198-207
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 85, No. 4 ( 2016), p. 198-207
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neurotrophic factor (BDNF). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this randomized and rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the modified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r 〈 i 〉 = 〈 /i 〉 -0.29, p = 0.02 at PI) and HCI (r 〈 i 〉 = 〈 /i 〉 -0.27, p = 0.03 at 6-month follow-up) groups, respectively. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000442261
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1472321-9
    detail.hit.zdb_id: 209490-3
    SSG: 5,2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 48, No. 3 ( 2018), p. 959-970
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 48, No. 3 ( 2018), p. 959-970
    Abstract: Background/Aims: Radiation-induced skin fibrosis is a common side effect of clinical radiotherapy. Our previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has been reported to target the PIK3-FOXO3 pathway. In this study, we investigated the effects of metformin on radiation-induced skin fibrosis. Methods: Metformin was orally administered to irradiated mice. Skin fibrosis was analyzed by staining with H & E and Masson’s trichrome stain. The levels of cytokines and chemokines associated with fibrosis were analyzed by immunohistochemistry and quantitative RT-PCR. The roles of PIK3rl and FOXO3 in radiation-induced skin fibrosis were studied by overexpressing PIK3rl and transfecting FOXO3 siRNA in NIH3T3 cells and mouse-derived dermal fibroblasts (MDF). Results: The oral administration of metformin significantly reduced radiation-induced skin thickening and collagen accumulation and significantly reduced the radiation-induced expression of FOXO3 in murine skin. Additionally, the overexpression of PIK3r1 reduced the radiation-induced expression of FOXO3, while FOXO3 silencing decreased the radiation-induced expression of TGFβ in vitro. Conclusions: The results indicated that metformin suppresses radiation-induced skin injuries by modulating the expression of FOXO3 through PIK3r1. Collectively, the data obtained in this study suggested that metformin could be a potent therapeutic agent for alleviating radiation-induced skin fibrosis.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000491964
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    detail.hit.zdb_id: 1067572-3
    SSG: 12
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Is Alpha Wave Neurofeedback Effective with Randomized Clinical Trials in Depression? A Pilot Study
    S. Karger AG ; 2011
    In:  Neuropsychobiology Vol. 63, No. 1 ( 2011), p. 43-51
    Details
    In: Neuropsychobiology, S. Karger AG, Vol. 63, No. 1 ( 2011), p. 43-51
    Abstract: Frontal asymmetric activation has been proposed to be the underlying mechanism for depression. Some case studies have reported that the enhancement of a relative right frontal alpha activity by an asymmetry neurofeedback training leads to improvement in depressive symptoms. In the present study, we examined whether a neurofeedback training designed to increase the relative activity of the right frontal alpha band would have an impact on symptoms of depressive subjects suffering from emotional, behavioral, and cognitive problems. Our results indicated that the asymmetry neurofeedback training increased the relative right frontal alpha power, and it remained effective even after the end of the total training sessions. In contrast to the training group, the placebo control group did not show a difference. The neurofeedback training had profound effects on emotion and cognition. First, we replicated earlier findings that enhancing the left frontal activity led to alleviation of depressive symptoms. Moreover, cognitive tests revealed that the asymmetry training improved performance of executive function tests, whereas the placebo treatment did not show improvement. We preliminarily concluded that the asymmetry training is important for controlling and regulating emotion, and it may facilitate the left frontal lobe function.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    URL: Article
    DOI: 10.1159/000322290
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483094-2
    detail.hit.zdb_id: 442239-9
    SSG: 5,2
    SSG: 15,3
    Location Call Number Limitation Availability
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  • 5
    Online Resource
    Online Resource
    Induction of Apoptosis by 〈i〉(Z)〈/i〉-Stellettic Acid C, an Acetylenic Acid from the Sponge 〈i〉Stelletta〈/i〉 sp., Is Associated with Inhibition of Telomerase Activity in Human Leukemic U937 Cells
    S. Karger AG ; 2007
    In:  Chemotherapy Vol. 53, No. 3 ( 2007), p. 160-168
    Details
    In: Chemotherapy, S. Karger AG, Vol. 53, No. 3 ( 2007), p. 160-168
    Abstract: 〈 i 〉 Background: 〈 /i 〉 ( 〈 i 〉 Z 〈 /i 〉 )-Stellettic acid C, an acetylenic acid from the marine sponge 〈 i 〉 Stelletta 〈 /i 〉 sp., has been shown to have cytotoxic activity in some cancer cells; however, its mechanisms on malignant cell growth are not known. In this study, the potential of ( 〈 i 〉 Z 〈 /i 〉 )-stellettic acid C to induce apoptosis in human leukemic U937 cells and its effects on telomerase activity were investigated. 〈 i 〉 Methods: 〈 /i 〉 Cytotoxicity was evaluated by MTT assays. Apoptosis was detected using DAPI staining and annexin V fluorescein. The mRNAs of Bcl-2, inhibitor of apoptosis proteins (IAPs) family and Fas/FasL system were determined by RT-PCR. Caspases and telomerase activities were measured using colorimetric assay and telomeric repeat amplification protocol enzyme-linked immunosorbent assay (TRAP-ELISA), respectively. 〈 i 〉 Results: 〈 /i 〉 Exposure of U937 cells to ( 〈 i 〉 Z 〈 /i 〉 )-stellettic acid C resulted in growth inhibition and induction of apoptosis in a dose-dependent manner, which was associated with the modulation of Bcl-2 family expression, activation of caspases and downregulation of IAPs family members. ( 〈 i 〉 Z 〈 /i 〉 )-Stellettic acid C treatment markedly inhibited the activity of telomerase in a dose-dependent fashion. Additionally, the expression of human telomerase reverse transcriptase, a main determinant of the telomerase enzymatic activity, was progressively downregulated by ( 〈 i 〉 Z 〈 /i 〉 )-stellettic acid C treatment. 〈 i 〉 Conclusions: 〈 /i 〉 These results suggest that ( 〈 i 〉 Z 〈 /i 〉 )-stellettic acid C could have a possible cancer therapeutic potential.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000100809
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482111-4
    detail.hit.zdb_id: 6708-8
    SSG: 15,3
    Location Call Number Limitation Availability
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