In:
Nanomedicine, Future Medicine Ltd, Vol. 10, No. 24 ( 2015-12), p. 3547-3562
Abstract:
Aim: To investigate the biological fate of cuprous oxide nanoparticles (Cu 2 O-NPs) and to evaluate their potential in uveal melanoma therapy. Materials & methods: The protein corona, cellular uptake mechanism and localization of Cu 2 O-NPs were investigated. Furthermore, the effect of Cu 2 O-NPs on uveal melanoma cell proliferation, migration and invasion, and possible mechanisms were studied in detail. Results: Cu 2 O-NPs are able to adsorb serum proteins in cell culture medium, which are then internalized by uveal melanoma cells mainly through lipid raft-mediated endocytosis. Furthermore, Cu 2 O-NPs selectively inhibit cancer cell growth and impair the ability of uveal melanoma cell migration, invasion and the cytoskeleton assembly. The mechanism may be that Cu 2 O-NPs located in and damage mitochondria, autophagolysosomes and lysosomes, leading to elevated reactive oxygen species level and over-stimulated apoptosis and autophagy. Conclusion: The data provide detailed information of Cu 2 O-NPs for further application and indicate that Cu 2 O-NPs could be a potential agent for uveal melanoma therapy.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2015
SSG:
15,3
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