In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 23, No. 3 ( 1983-03), p. 422-428
Abstract:
The belief that a favorable physiological milieu in the urinary tract may augment the effectiveness of antimicrobial agents used to treat urinary tract infections was examined by using an experimental model of Escherichia coli-induced renal infection in rats. The effect of manipulating urinary pH and flow on the antimicrobial activities of gentamicin, carbenicillin, ampicillin, nitrofurantoin and co-trimoxazole was assessed. In addition, a potential synergistic effect of the sequential administration of gentamicin and cephalothin in the eradication of renal infection was investigated. Although significant physiological alterations were achieved, these did not affect the efficacy of the antimicrobial agents studied, and therapeutic failures were common.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.23.3.422
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1983
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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