In:
Bioanalysis, Future Science Ltd, Vol. 4, No. 10 ( 2012-06), p. 1205-1213
Kurzfassung:
Background: Dahuang Huanglian Xiexin Decoction (DHXD) is a classical formula in traditional Chinese medicines. In this study, a novel UPLC-MS/MS method was developed for the simultaneous quantification of rhein, emodin, berberine and baicalin, the major bioactive compounds of DHXD in rat plasma. Results: The method possessed high sensitivity and ultrashort analysis time (7 min). Linearity, accuracy, precision and extraction recovery of four analytes were all satisfactory. The method was then successfully applied in a pharmacokinetic study of four bioactive components after a single oral administration of DHXD extract to rats. Conclusion: The method was applicable for simultaneous bioanalysis of rhein, emodin, berberine and baicalin.
Materialart:
Online-Ressource
ISSN:
1757-6180
,
1757-6199
Sprache:
Englisch
Verlag:
Future Science Ltd
Publikationsdatum:
2012
SSG:
15,3
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