In:
Drug Development Research, Wiley, Vol. 75, No. 2 ( 2014-03), p. 76-87
Abstract:
Preclinical Research The preparation of novel E ‐salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E ‐salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical 1 H NMR , 13 C NMR , and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA ‐ MB ‐231 cells by using a transwell assay. Comparing with the positive control, LY 294002, compounds 19b , 19d , and 19e exhibited significant inhibitory effects on the EGF ‐induced invasion of MB ‐ MDA ‐231 cells. Moreover, compound 19b also had antimigration effects in wound‐healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.
Type of Medium:
Online Resource
ISSN:
0272-4391
,
1098-2299
DOI:
10.1002/ddr.2014.75.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1500191-X
SSG:
15,3
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