In:
Pharmacogenomics, Future Medicine Ltd, Vol. 16, No. 10 ( 2015-07), p. 1077-1088
Abstract:
Aim: To investigate the association between SOST gene polymorphisms and response to alendronate treatment. Materials & methods: 639 Chinese postmenopausal women with osteoporosis or osteopenia received alendronate treatment. Polymorphisms of SOST were analyzed. Bone mineral density (BMD), serum ALP and β-CTX levels were measured. The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed. Results: rs1234612 and rs851054 polymorphisms were correlated to baseline lumbar spine BMD (p 〈 0.05). After 12 months of treatment rs1234612 and rs865429 polymorphisms were correlated to BMD changes at the lumbar spine (p 〈 0.05) or femoral neck (p 〈 0.05), respectively. Conclusion: The polymorphisms of SOST are genetic factors affecting bone health and response to alendronate in Chinese postmenopausal women.
Type of Medium:
Online Resource
ISSN:
1462-2416
,
1744-8042
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2015
SSG:
15,3
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