In:
Chemotherapy, S. Karger AG, Vol. 58, No. 3 ( 2012), p. 212-216
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Neuronal injury in pneumococcal meningitis is a consequence of microglial activation and direct toxicity by bacterial products and systemic inflammation. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The treatment effect of the TEPC-15 antibody recognizing teichoic and lipoteichoic acids was investigated in murine microglial cells and in a rabbit model of pneumococcal meningitis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In vitro, the TEPC-15 antibody recognizing teichoic and lipoteichoic acids increased 〈 i 〉 Streptococcus pneumoniae 〈 /i 〉 phagocytosis by murine microglial cells. In rabbit ceftriaxone-treated 〈 i 〉 S. pneumoniae 〈 /i 〉 meningitis, intracisternal TEPC-15 reduced the density of apoptotic neurons in the hippocampal dentate gyrus (116 ± 70 vs. 221 ± 132/mm 〈 sup 〉 2 〈 /sup 〉 ; p = 0.03). Cerebrospinal fluid inflammatory parameters (protein, lactate, leukocytes, prostaglandins) were not reduced in TEPC-15-treated rabbits. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Intracisternal treatment with the TEPC-15 antibody reduced neuronal damage probably by promoting rapid phagocytosis of bacterial products.
Type of Medium:
Online Resource
ISSN:
0009-3157
,
1421-9794
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482111-4
SSG:
15,3
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