In:
Pharmacogenomics, Future Medicine Ltd, Vol. 22, No. 17 ( 2021-11), p. 1135-1142
Abstract:
Aim: To evaluate the associations between human leukocyte antigen ( HLA)-DRB1 variants and the rs6021191 variant in nuclear factor of activated T cells 2 ( NFATC2) with PEG-asparaginase hypersensitivity in children with acute lymphoblastic leukemia (ALL) treated according to the Chinese Children Leukemia Group (CCLG) ALL 2018 protocol. Methods: HLA-DRB1 genotyping was performed using a PCR sequence-based typing (SBT) method. NFATC2 rs6021191 was genotyped applying TaqMan Genotyping Assay. Results: T-ALL and higher risk groups were at higher risk for PEG-asparaginase hypersensitivity. No association was found between NFATC2 rs6021191 and PEG-asparaginase hypersensitivity. HLA-DRB1*16:02 variant was associated with PEG-asparaginase allergy both in univariate and multivariate logistic regression analysis. Conclusion: Our results confirm that variations in HLA-DRB1 might influence the development of asparaginase hypersensitivity.
Type of Medium:
Online Resource
ISSN:
1462-2416
,
1744-8042
DOI:
10.2217/pgs-2021-0107
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2021
SSG:
15,3
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