In:
British Journal of Clinical Pharmacology, Wiley, Vol. 84, No. 1 ( 2018-01), p. 79-87
Abstract:
The preventive effect of once‐daily rivaroxaban, which has a short half‐life, on stroke and/or systemic embolism is equal or superior to that of warfarin. What this Study Adds Residual plasma rivaroxaban at the trough steady state can be traced. Factor Xa inhibition by rivaroxaban in the trough steady state can downregulate and reduce thrombin generation. Rivaroxaban's antithrombin effect at the trough steady state may play a role in the prevention of thromboembolic events in patients with nonvalvular atrial fibrillation.
Type of Medium:
Online Resource
ISSN:
0306-5251
,
1365-2125
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1498142-7
SSG:
15,3
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