In:
Phytotherapy Research, Wiley, Vol. 26, No. 10 ( 2012-10), p. 1569-1571
Abstract:
The present work evaluates the effect of olive oil phenols on NF‐κB activity in human gastric adenocarcinoma cells. The total phenol content was measured by the Folin Ciocalteu method, whereas the composition was assessed by LC‐MS/MS analysis. Secoiridoids represented 71% and 83% of the Italian and Spanish extracts, respectively, phenol alcohols were in the range 9–13%. Ligustroside aglycone was the most abundant (37% and 46%, respectively, in the Italian and Spanish sample), and the concentration of flavonoids AP and LU was below 1%. Phenol extracts were assayed at 0.25–7.5 µg/mL, whereas single compounds were at 0.5–25 µ m . Both the extracts inhibited the NF‐κB driven transcription in a concentration‐dependent manner: IC 50 for the Italian and the Spanish extract were 0.86 and 1.28 µg/mL, respectively. The IC 50 for individual compounds ranged from 4.5 to 13 µ m . All the compounds under study inhibited nuclear translocation as well. The data suggest that consumption of extra‐virgin olive oil may be beneficial for preventing the onset of gastric inflammation leading to more serious diseases. Copyright © 2012 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0951-418X
,
1099-1573
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1493490-5
SSG:
15,3
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