In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 58, No. 1 ( 2014-01), p. 587-589
Kurzfassung:
A phospholipid-based nanoemulsion formulation of SQ641 (SQ641-NE) was active against intracellular Mycobacterium tuberculosis in J774A.1 mouse macrophages, although SQ641 by itself was not. Intravenous (i.v.) SQ641-NE was cleared from circulation and reached peak concentrations in lung and spleen in 1 h. In a murine tuberculosis (TB) model, 8 i.v. doses of SQ641-NE at 100 mg/kg of body weight over 4 weeks caused a 1.73 log 10 CFU reduction of M. tuberculosis in spleen and were generally bacteriostatic in lungs.
Materialart:
Online-Ressource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.01254-13
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2014
ZDB Id:
1496156-8
SSG:
12
SSG:
15,3
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