In:
Antibiotics, MDPI AG, Vol. 9, No. 6 ( 2020-05-26), p. 278-
Abstract:
An antifungal lipodepsipeptide was obtained from cultures of the fungus Foliophoma fallens CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecanoic acid. The absolute configuration of its amino acid residues was determined using Marfey’s analysis and J-based configuration analysis helped to establish the relative configuration of the 3-hydroxy-4-methylhexadecanoic acid moiety. A literature search retrieved a patent describing antibiotic TKR2999 (1), whose non-disclosed structure was confirmed to be identical to that found for our compound, according to its physicochemical properties and NMR spectra. Compound 1 displayed potent antifungal activity against Aspergillus fumigatus and a panel of Candida strains.
Type of Medium:
Online Resource
ISSN:
2079-6382
DOI:
10.3390/antibiotics9060278
Language:
English
Publisher:
MDPI AG
Publication Date:
2020
detail.hit.zdb_id:
2681345-2
SSG:
15,3
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