In:
Tropical Journal of Pharmaceutical Research, African Journals Online (AJOL), Vol. 21, No. 2 ( 2022-04-28), p. 409-416
Abstract:
Purpose: To examine the efficacy of percutaneous transluminal angioplasty (PTA), combined withpharmacologic thrombolysis (PT) on thrombosis of autologous arteriovenous fistulas (AVFs),inflammatory factors, and β2 microglobulin (β2-MG) levels in hemodialysis patients.Methods: Seventy-eight patients with AVF thrombosis allocated randomly into a control group (CG) received PTA, and a study group (SG) received PTA combined with PT (n = 39 in each). The patency, vascular condition, inflammatory factors, viz, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP)), β2-MG levels, vascular-related factors (VEGF-A and MCP-1), complications, and quality of life were determined.Results: At three and six months after surgery, t SG exhibited a higher vascular patency than CG (p 〈 0.05). Serum levels of IL-6, hs-CRP, β2-MG, VEGF-A, and MCP-1 of t SG were lower than those of CG(p 〈 0.05). The SG showed higher cross-sectional area, inner diameter at the site of fistula, and better quality of life scores than CG (p 〈 0.05).Conclusion: The combination of PTA and PT enhances efficacy, increases vascular patency, reduces inflammatory response, lowers the level of β2-MG, and improves quality of life in patients with AVFs without increasing complications. Thus, the combination treatment has potentials for the management of hemodialysis patients.
Type of Medium:
Online Resource
ISSN:
1596-9827
,
1596-5996
DOI:
10.4314/tjpr.v21i2.26
Language:
Unknown
Publisher:
African Journals Online (AJOL)
Publication Date:
2022
detail.hit.zdb_id:
2125881-8
SSG:
15,3
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