In:
The EMBO Journal, EMBO, Vol. 40, No. 4 ( 2021-02-15)
Abstract:
image Aberrant activation of the Wnt/β‐catenin pathway can promote stem cell self‐renewal and expansion in cancer. Here, mislocalized secretory proteoglycan ESM1 is implicated in the nuclear coordination of Wnt/β‐catenin signaling, thus supporting prostate cancer (PCa) stemness and metastasis. Nuclear ESM1 regulates PCa metastasis by promoting cancer stem cell properties. ESM1 associates with β‐catenin to stabilize the β‐catenin/TCF4 complex and promote Wnt activation. A positive feed‐forward loop between activated β‐catenin and nuclear ESM1 maintains Wnt‐mediated PCa stemness.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2020105450
Language:
English
Publisher:
EMBO
Publication Date:
2021
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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