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  • SAGE Publications  (16)
  • English  (16)
  • Pharmacy  (16)
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  • Pharmacy  (16)
  • 1
    Online Resource
    Online Resource
    New Unsaturated Lactones and a Meroterpenoid from Ganoderma lucidum
    SAGE Publications ; 2019
    In:  Natural Product Communications Vol. 14, No. 7 ( 2019-07), p. 1934578X1985881-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 14, No. 7 ( 2019-07), p. 1934578X1985881-
    Abstract: From the dried fruiting bodies of Ganoderma lucidum, 2 new unsaturated lactones, dayaolingzhilactones A and B (1 and 2), and 1 new meroterpenoid, dayaolingzhiol H (3), together with 10 known compounds (4-13), were isolated. Their chemical structures were identified by using spectroscopic data and calculated specific rotation. The inhibitory activities of compounds 1 and 2 toward acetylcholinesterase (AchE) were assessed in vitro with tacrine as the positive control. Both of them exhibited moderate AchE inhibitory activities at the concentration of 50 μM.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X19858815
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2430442-6
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  • 2
    Online Resource
    Online Resource
    With Guide of Spike-in Experiment for Optimizing Workflow of LC-MS data Processing in Metabolomics
    SAGE Publications ; 2017
    In:  Natural Product Communications Vol. 12, No. 8 ( 2017-08), p. 1934578X1701200-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 12, No. 8 ( 2017-08), p. 1934578X1701200-
    Abstract: A systematical study was performed to investigate the processing workflow of LC-MS-based metabolomics data by optimizing parameter settings in XCMS software and comparing different preprocessing methods. Here we use a spike-in experiment combining with design of experiment (DoE) approaches for optimizing XCMS software parameters. A trusted index, which was based on accuracy evaluation of the spike-in data, was employed to assess the optimizing process. After optimizing the XCMS setting, the trusted index was improved from 3.67 to 30 and positive rate of spike-in standards also increased from 20% to 100%. Moreover, different data preprocessing methods, such as normalization, different scaling methods were also investigated on spike-in data since they were found to affect the outcome of the data analysis and ions features identification. Accordingly, UN-normalization and Pareto scaling were chosen as appropriate preprocessing methods to deal with LC-MS data through the evaluation of match index (mainly applied multivariate statistics methods). Finally, the optimized workflow was applied to experimental samples that acquired from metabolomics experiment and analyzed randomly with spike-in sample, which indicated a better applicability in formal metabolomics experiment. It is concluded that the proposed data processing workflow could be used as feasible approach for improving the quality of LC-MS-based metabolomics data and ensured the veracity of metabolites identification in data processing procedures to a certain extent.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1701200837
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2430442-6
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  • 3
    Online Resource
    Online Resource
    Proteomic Analysis of the Antibacterial Mechanism of Action of Juglone against Staphylococcus aureus
    SAGE Publications ; 2016
    In:  Natural Product Communications Vol. 11, No. 6 ( 2016-06), p. 1934578X1601100-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 11, No. 6 ( 2016-06), p. 1934578X1601100-
    Abstract: Juglone is a plant-derived 1,4-naphthoquinone with confirmed antibacterial activity. However, the mechanism of action of juglone against Staphylococcus aureus remains unclear. Possible mechanisms were explored by a proteomic analysis of S. aureus proteins that are inhibited by juglone. Two-dimensional gel electrophoresis revealed that 21 protein spots were differentially expressed between juglone-treated and untreated cells of which 13 were identified. A bioinformatic analysis revealed that proteins participating in protein synthesis, the tricarboxylic acid cycle, as well as DNA and RNA synthesis were inhibited by juglone, thus leading to cell collapse. These findings provide clues regarding the mechanism of action of juglone, which can be effective for treating cases of S. aureus infection.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1601100632
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2430442-6
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  • 4
    Online Resource
    Online Resource
    Reduced emergency room visits and improved medication adherence of an integrated oncology pharmaceutical care practice in China
    SAGE Publications ; 2021
    In:  Journal of Oncology Pharmacy Practice Vol. 27, No. 6 ( 2021-08), p. 1503-1515
    Details
    In: Journal of Oncology Pharmacy Practice, SAGE Publications, Vol. 27, No. 6 ( 2021-08), p. 1503-1515
    Abstract: We described our initial experience of a new integrated oncology phamaceutical care practice to enhance the quality of pharmacy service and patient care in Huashan hospital. Data sources: A retrospective study was performed from August 2019 to September 2020. Patients were described as integrated pharmacy service group and routine care group. Medication adherence of patients in integrated pharmacy service group was recorded by the online management system. Patient satisfaction and the cumulative incidence of emergency room (ER) and outpatient visit were evaluated between two groups. Data summary: In total, 323 patients received the integrating oncology pharmacy service. The percentage of the patients missing administration every day was reduced from 29.7% to 0.3% within a 40-day monitoring and intervention period. There was a significant difference on patient satisfaction with pharmacy service in two groups ( P 〈 0.05). Fewer patients in the integrated pharmacy service group visited clinic and ER compared with routine care group (33.1% vs. 59.2%; P 〈 0.05). Conclusions As a new practice model, the integrated program is adopted to provide patient care and ongoing monitoring for cancer patients. The practice model delivers high continuity of care for cancer patients and improves communication and collaboration between healthcare professionals and oncology patients. The practice also provides the potential of developing hospital pharmaceutical service and optimizing disease prevention and treatment strategies.
    Type of Medium: Online Resource
    ISSN: 1078-1552 , 1477-092X
    URL: Article
    DOI: 10.1177/10781552211027218
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2026590-6
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  • 5
    Online Resource
    Online Resource
    Association of Serum Total Cholesterol with Pegylated Interferon-α Treatment in HBeAg-Positive Chronic Hepatitis B Patients
    SAGE Publications ; 2019
    In:  Antiviral Therapy Vol. 24, No. 2 ( 2019-02), p. 85-93
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 24, No. 2 ( 2019-02), p. 85-93
    Abstract: Recent studies suggest that serum lipids are associated with pegylated interferon-alpha (PEG-IFN-α) treatment response in chronic hepatitis C patients. However, the role of serum lipids in influencing the outcome of HBV treatment is not well understood. This study aims to investigate the association of serum lipids with the response to interferon-alpha treatment for chronic hepatitis B (CHB) patients. Methods We dynamically measured 11 clinical serum lipid parameters of 119 hepatitis B e antigen (HBeAg)-positive CHB patients, including 53 patients who achieved sustained response (SR) and 66 patients who achieved non-response (NR) induced by PEG-IFN-α treatment for 48 weeks. Results The dynamic analysis showed that the baseline serum total cholesterol (TCHO) level was higher in the NR group than that in the SR group ( P=0.004). Moreover, the correlation analysis demonstrated a significant positive correlation between TCHO and hepatitis B surface antigen (HBsAg) at baseline ( P=0.009). In addition, CHB patients with high baseline TCHO levels exhibited higher HBV DNA, HBsAg, HBeAg and hepatitis B e antibody (HBeAb) levels during early treatment periods (weeks 0, 4, 12 and 24) than those with the low TCHO levels. Furthermore, the logistic regression analysis identified that baseline serum TCHO was a risk factor for NR achievement (OR=4.94; P=0.047). Conclusions: Our results indicated that serum TCHO was associated with PEG-IFN-α therapeutic response in HBeAg-positive CHB patients which suggested that serum TCHO could be useful as an auxiliary clinical factor to predict poor efficacy of PEG-IFN-α therapy.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP3282
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2118396-X
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  • 6
    Online Resource
    Online Resource
    New Cytotoxic Triterpene Glycoside from the East China Sea Cucumber Holothuria nobilis
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Abstract: A new cytotoxic triterpene glycoside named nobiliside E (1) has been obtained from the East China Sea cucumber Holothuria nobilis Selenka. Its structure was determined on the basis of NMR spectroscopic and MS analyses, together with chemical evidence. The new compound showed significant cytotoxicity to eight human tumor cell lines with IC 50 values in the range of 0.53–4.06 μg/mL.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501000207
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
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  • 7
    Online Resource
    Online Resource
    Two 2-Phenylbenzofuran Derivatives from Morus atropurpurea
    SAGE Publications ; 2013
    In:  Natural Product Communications Vol. 8, No. 5 ( 2013-05), p. 1934578X1300800-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 8, No. 5 ( 2013-05), p. 1934578X1300800-
    Abstract: Two new 2-phenylbenzofuran derivatives, atrofuran A (1) and atrofuran B (2), along with five known compounds, were isolated from the root bark of Morus atropurpurea. The structures of the new compounds were determined on the basis of extensive NMR spectroscopic and HR-ESI-MS analyses.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1300800514
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2430442-6
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  • 8
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    Online Resource
    Antibacterial and Antibiofilm Effects of Zanthoxylum bungeanum Leaves against Staphylococcus aureus
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 8 ( 2018-08), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 8 ( 2018-08), p. 1934578X1801300-
    Abstract: Biofilm formation by Staphylococcus aureus on food contact surfaces is one of the most important issues for the food safety. The difficulties in controlling biofilms have driven the search for new antibacterial and antibiofilm agents from natural resources. The aims of the present study were to investigate the antibacterial and antibiofilm activities of the methanolic extract from Zanthoxylum bungeanum Maxim. leaves and identify the active compounds. By bioassay guide of inhibitory activity against S. aureus, four antibacterial compounds were separated from this extract and identified as neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and 4- O-caffeoyl-2,3-dihydroxy-2- C-methylbutyric acid based on MS and NMR data analyses. The four compounds exhibited moderate antibacterial activity against S. aureus with minimum inhibitory concentration of 5 mg/mL. Moreover, a fraction consisted of the four compounds was subjected to antibiofilm assays against S. aureus. Crystal violet staining and XTT reduction assay demonstrated that this fraction showed an excellent inhibitory efficacy on the biomass and metabolic activity of S. aureus biofilm. Scanning electron microscopic observation displayed that this fraction induced severe morphological changes in the architecture of S. aureus biofilm, which further confirmed that it possessed a potent inhibitory activity on the biofilm formation of S. aureus. So, these results suggested that Z. bungeanum leaves could be used as an attractive and promising candidate for the development of natural antibacterial agent for controlling food-related bacterial biofilms.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300819
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2430442-6
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  • 9
    Online Resource
    Online Resource
    Chemical Constituents of Callicarpa giraldii and Their Anti-Inflammatory Activity
    SAGE Publications ; 2021
    In:  Natural Product Communications Vol. 16, No. 10 ( 2021-10), p. 1934578X2110518-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 16, No. 10 ( 2021-10), p. 1934578X2110518-
    Abstract: Callicarpa giraldii (family Verbenaceae) has many medical properties and is commonly used in traditional Chinese medicine. However, its chemical constituents have not been investigated. In this study, nine compounds present in the leaves and stems were isolated and characterized. These were negundonorin B (1), lupeol (2), erythrodiol (3), isoacteoside (4), forsythoside B (5), dibutyl phthalate (6), verbascoside (7), poliumoside (8), and 3-methoxy-4-hydroxybenzaldehyde (9). The structures were identified by comparison of their NMR data with those reported in the literature. The anti-inflammatory effects of compounds 1-6 were tested on lipopolysaccharide-stimulated RAW264.7 macrophages. Several compounds showed significant ( p  〈  .05) inhibitory effects.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X211051801
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2430442-6
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  • 10
    Online Resource
    Online Resource
    Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 10 ( 2022-10), p. 1934578X2211308-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 10 ( 2022-10), p. 1934578X2211308-
    Abstract: Cryptotanshinone is a quinone diterpene extracted from the traditional Chinese medicine Salvia miltiorrhiza root that shows obvious anticancer activity. The aim of this study was to investigate the mechanism of action of cryptotanshinone as an antigastric cancer agent, as well as a chemotherapy potentiator. A gastric cancer model was established by tumor transplantation, and mice were treated with either 5-fluorouracil or cryptotanshinone, or both drugs. The tumor mass was recorded, and the tumor suppression rate was calculated. Pathological changes were observed by hematoxylin and eosin staining, gene transcription was detected by quantitative polymerase chain reaction, and protein expression by Western blotting. The results showed that cryptotanshinone could reduce the tumor mass, increase the tumor suppression rate, and enhance the chemotherapeutic effect of 5-fluorouracil by a mechanism related to inhibition of the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221130874
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2430442-6
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