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  • 1
    Online Resource
    Online Resource
    The neural encoding of productive phonological alternation in speech production: Evidence from Mandarin Tone 3 sandhi
    Elsevier BV ; 2022
    In:  Journal of Neurolinguistics Vol. 62 ( 2022-05), p. 101060-
    Details
    In: Journal of Neurolinguistics, Elsevier BV, Vol. 62 ( 2022-05), p. 101060-
    Type of Medium: Online Resource
    ISSN: 0911-6044
    URL: Article
    DOI: 10.1016/j.jneuroling.2022.101060
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1480525-X
    SSG: 7,11
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  • 2
    Online Resource
    Online Resource
    Dissecting primate early post-implantation development using long-term in vitro embryo culture
    American Association for the Advancement of Science (AAAS) ; 2019
    In:  Science Vol. 366, No. 6467 ( 2019-11-15)
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 366, No. 6467 ( 2019-11-15)
    Abstract: The transition from peri-implantation to gastrulation in mammals entails the specification and organization of the lineage progenitors into a body plan. Technical and ethical challenges have limited understanding of the cellular and molecular mechanisms that underlie this transition. We established a culture system that enabled the development of cynomolgus monkey embryos in vitro for up to 20 days. Cultured embryos underwent key primate developmental stages, including lineage segregation, bilaminar disc formation, amniotic and yolk sac cavitation, and primordial germ cell–like cell (PGCLC) differentiation. Single-cell RNA-sequencing analysis revealed development trajectories of primitive endoderm, trophectoderm, epiblast lineages, and PGCLCs. Analysis of single-cell chromatin accessibility identified transcription factors specifying each cell type. Our results reveal critical developmental events and complex molecular mechanisms underlying nonhuman primate embryogenesis in the early postimplantation period, with possible relevance to human development.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aaw5754
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector
    Proceedings of the National Academy of Sciences ; 2010
    In:  Proceedings of the National Academy of Sciences Vol. 107, No. 41 ( 2010-10-12), p. 17663-17667
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 107, No. 41 ( 2010-10-12), p. 17663-17667
    Abstract: The development of transgenic technologies in monkeys is important for creating valuable animal models of human physiology so that the etiology of diseases can be studied and potential therapies for their amelioration may be developed. However, the efficiency of producing transgenic primate animals is presently very low, and there are few reports of success. We have developed an improved methodology for the production of transgenic rhesus monkeys, making use of a simian immunodeficiency virus (SIV)-based vector that encodes EGFP and a protocol for infection of early-cleavage–stage embryos. We show that infection does not alter embryo development. Moreover, the timing of infection, either before or during embryonic genome activation, has no observable effect on the level and stability of transgene expression. Of 70 embryos injected with concentrated virus at the one- to two-cell stage or the four- to eight-cell stage and showing fluorescence, 30 were transferred to surrogate mothers. One transgenic fetus was obtained from a fraternal triple pregnancy. Four infant monkeys were produced from four singleton pregnancies, of which two expressed EGFP throughout the whole body. These results demonstrate the usefulness of SIV-based lentiviral vectors for the generation of transgenic monkeys and improve the efficiency of transgenic technology in nonhuman primates.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1006563107
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2010
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Perceptual preference for falling tones over rising tones: A study of Mandarin Chinese
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1911-1911
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1911-1911
    Abstract: Typological studies have shown that there are more falling tones than rising tones in tone languages, including Chinese. We test the hypothesis that this may be due to a perceptually-based advantage for falling tones over rising tones. Two acoustically comparable (and matched for naturalness) tonal continua in Mandarin (level-falling T1-T4, and level-rising T1-T2) were created. Identification and discrimination results were obtained from 14 native Mandarin speakers. The results revealed that it is easier to identify a falling tone than a rising tone; that is, listeners require a smaller F0 difference between onset and offset to distinguish a falling tone from a level tone as compared to a rising tone from a level tone. Additionally, there are several hints of better discrimination for the falling continuum. This disagrees with our and others’ Mandarin production data, which show that the rising tone is closer to the level tone than the falling tone is, hence a production-perception dissociation. We propose that, historically, Chinese listeners’ greater sensitivity to the level-falling contrast has resulted in the preponderance of falling tones over rising tones found across Chinese languages, and this proposed explanation may be applicable to other tone languages as well.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5101934
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Broadband surface-wave transformation cloak
    Proceedings of the National Academy of Sciences ; 2015
    In:  Proceedings of the National Academy of Sciences Vol. 112, No. 25 ( 2015-06-23), p. 7635-7638
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 112, No. 25 ( 2015-06-23), p. 7635-7638
    Abstract: Guiding surface electromagnetic waves around disorder without disturbing the wave amplitude or phase is in great demand for modern photonic and plasmonic devices, but is fundamentally difficult to realize because light momentum must be conserved in a scattering event. A partial realization has been achieved by exploiting topological electromagnetic surface states, but this approach is limited to narrow-band light transmission and subject to phase disturbances in the presence of disorder. Recent advances in transformation optics apply principles of general relativity to curve the space for light, allowing one to match the momentum and phase of light around any disorder as if that disorder were not there. This feature has been exploited in the development of invisibility cloaks. An ideal invisibility cloak, however, would require the phase velocity of light being guided around the cloaked object to exceed the vacuum speed of light—a feat potentially achievable only over an extremely narrow band. In this work, we theoretically and experimentally show that the bottlenecks encountered in previous studies can be overcome. We introduce a class of cloaks capable of remarkable broadband surface electromagnetic waves guidance around ultrasharp corners and bumps with no perceptible changes in amplitude and phase. These cloaks consist of specifically designed nonmagnetic metamaterials and achieve nearly ideal transmission efficiency over a broadband frequency range from 0 + to 6 GHz. This work provides strong support for the application of transformation optics to plasmonic circuits and could pave the way toward high-performance, large-scale integrated photonic circuits.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1508777112
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2015
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Coordination of mRNA and tRNA methylations by TRMT10A
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 14 ( 2020-04-07), p. 7782-7791
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 14 ( 2020-04-07), p. 7782-7791
    Abstract: The posttranscriptional modification of messenger RNA (mRNA) and transfer RNA (tRNA) provides an additional layer of regulatory complexity during gene expression. Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells. TRMT10A installs N 1 -methylguanosine (m 1 G) in tRNA, and FTO performs demethylation on N 6 -methyladenosine (m 6 A) and N 6 ,2′- O -dimethyladenosine (m 6 A m ) in mRNA. We show that TRMT10A ablation not only leads to decreased m 1 G in tRNA but also significantly increases m 6 A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs have accelerated decay rates potentially through the regulation by a specific m 6 A reader, YTHDF2. Furthermore, transcripts with increased m 6 A upon TRMT10A ablation contain an overrepresentation of m 1 G9-containing tRNAs codons read by tRNA Gln(TTG) , tRNA Arg(CCG) , and tRNA Thr(CGT) . These findings collectively reveal the presence of coordinated mRNA and tRNA methylations and demonstrate a mechanism for regulating gene expression through the interactions between mRNA and tRNA modifying enzymes.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1913448117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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