In:
Science, American Association for the Advancement of Science (AAAS), Vol. 349, No. 6251 ( 2015-08-28), p. 993-997
Abstract:
T regulatory cells that express the transcription factor Foxp3 (Foxp3 + T regs ) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a distinct T reg population in the mouse colon, which constrains immuno-inflammatory responses. This induction—which we find to map to a broad, but specific, array of individual bacterial species—requires the transcription factor Rorγ, paradoxically, in that Rorγ is thought to antagonize FoxP3 and to promote T helper 17 (T H 17) cell differentiation. Rorγ’s transcriptional footprint differs in colonic T regs and T H 17 cells and controls important effector molecules. Rorγ, and the T regs that express it, contribute substantially to regulating colonic T H 1/T H 17 inflammation. Thus, the marked context-specificity of Rorγ results in very different outcomes even in closely related cell types.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.aaa9420
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2015
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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