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  • 1
    Online Resource
    Online Resource
    Rules all PIs should follow
    American Association for the Advancement of Science (AAAS) ; 2022
    In:  Science Vol. 376, No. 6588 ( 2022-04), p. 24-26
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 376, No. 6588 ( 2022-04), p. 24-26
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.abp9887
    RVK:
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    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2022
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  • 2
    Online Resource
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    Real-time traffic jams prediction inspired by Biham, Middleton and Levine (BML) model
    Elsevier BV ; 2017
    In:  Information Sciences Vol. 381 ( 2017-03), p. 209-228
    Details
    In: Information Sciences, Elsevier BV, Vol. 381 ( 2017-03), p. 209-228
    Type of Medium: Online Resource
    ISSN: 0020-0255
    URL: Article
    DOI: 10.1016/j.ins.2016.11.023
    RVK:
    SA 5420
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
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  • 3
    Online Resource
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    Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy
    Proceedings of the National Academy of Sciences ; 2019
    In:  Proceedings of the National Academy of Sciences Vol. 116, No. 13 ( 2019-03-26), p. 6308-6312
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 116, No. 13 ( 2019-03-26), p. 6308-6312
    Abstract: Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of these studies were retrospective, using individuals previously diagnosed with cancer as cases and healthy individuals as controls. Here, we developed a liquid biopsy assay, named the hepatocellular carcinoma screen (HCCscreen), to identify HCC from the surface antigen of hepatitis B virus (HBsAg) positive asymptomatic individuals in the community population. The training cohort consisted of individuals who had liver nodules and/or elevated serum α-fetoprotein (AFP) levels, and the assay robustly separated those with HCC from those who were non-HCC with a sensitivity of 85% and a specificity of 93%. We further applied this assay to 331 individuals with normal liver ultrasonography and serum AFP levels. A total of 24 positive cases were identified, and a clinical follow-up for 6–8 mo confirmed four had developed HCC. No HCC cases were diagnosed from the 307 test-negative individuals in the follow-up during the same timescale. Thus, the assay showed 100% sensitivity, 94% specificity, and 17% positive predictive value in the validation cohort. Notably, each of the four HCC cases was at the early stage ( 〈 3 cm) when diagnosed. Our study provides evidence that the use of combined detection of cfDNA alterations and protein markers is a feasible approach to identify early stage HCC from asymptomatic community populations with unknown HCC status.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1819799116
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    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2019
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  • 4
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    Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA
    Proceedings of the National Academy of Sciences ; 2010
    In:  Proceedings of the National Academy of Sciences Vol. 107, No. 10 ( 2010-03-09), p. 4699-4704
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 107, No. 10 ( 2010-03-09), p. 4699-4704
    Abstract: Bacterial pathogens deliver effector proteins with diverse biochemical activities into host cells, thereby modulating various host functions. Legionella pneumophila hijacks host vesicle trafficking to avoid phagosome–lysosome fusion, a mechanism that is dependent on the Legionella Dot/Icm type IV secretion system. SidM/DrrA, a Legionella type IV effector, is important for the interactions of Legionella -containing vacuoles with host endoplasmic reticulum–derived vesicles. SidM is the only known protein that catalyzes both the exchange of GDP for GTP and GDI displacement from small GTPase Rab1. We determined the crystal structures of SidM alone (residues 317–647) and SidM (residues 193–550) in complex with nucleotide-free WT Rab1. The SidM structure contains an N-terminal helical domain with a potential new function, a Rab1-activation domain, and a C-terminal phosphatidylinositol 4-phosphate–binding P4M domain. The Rab1-activation domain has extensive strong interactions mainly with Rab1 switch I and II regions that undergo substantial conformational changes on SidM binding. Mutations of switch-contacting residues in SidM attenuate both the nucleotide exchange and GDI displacement activities. Structural comparisons of Rab1 in the SidM complex with Rab1-GDP and Ypt1-GDP in the GDI complex identify key conformational changes that disrupt the nucleotide and GDI binding of Rab1. Further biochemical and structural analyses reveal a unique mechanism of coupled GDP release and GDI displacement likely triggered by the SidM-induced drastic displacement of switch I of Rab1.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0914231107
    RVK:
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    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2010
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  • 5
    Online Resource
    Online Resource
    Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices
    Proceedings of the National Academy of Sciences ; 2003
    In:  Proceedings of the National Academy of Sciences Vol. 100, No. 14 ( 2003-07-08), p. 8103-8108
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 100, No. 14 ( 2003-07-08), p. 8103-8108
    Abstract: The programmed self-assembly of patterned aperiodic molecular structures is a major challenge in nanotechnology and has numerous potential applications for nanofabrication of complex structures and useful devices. Here we report the construction of an aperiodic patterned DNA lattice (barcode lattice) by a self-assembly process of directed nucleation of DNA tiles around a scaffold DNA strand. The input DNA scaffold strand, constructed by ligation of shorter synthetic oligonucleotides, provides layers of the DNA lattice with barcode patterning information represented by the presence or absence of DNA hairpin loops protruding out of the lattice plane. Self-assembly of multiple DNA tiles around the scaffold strand was shown to result in a patterned lattice containing barcode information of 01101. We have also demonstrated the reprogramming of the system to another patterning. An inverted barcode pattern of 10010 was achieved by modifying the scaffold strands and one of the strands composing each tile. A ribbon lattice, consisting of repetitions of the barcode pattern with expected periodicity, was also constructed by the addition of sticky ends. The patterning of both classes of lattices was clearly observable via atomic force microscopy. These results represent a step toward implementation of a visual readout system capable of converting information encoded on a 1D DNA strand into a 2D form readable by advanced microscopic techniques. A functioning visual output method would not only increase the readout speed of DNA-based computers, but may also find use in other sequence identificati on techniques such as mutation or allele mapping.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1032954100
    RVK:
    TA 1000
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    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2003
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  • 6
    Online Resource
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    Detecting residual stress on toughened glass surface by two complementary interferometers
    IOP Publishing ; 2021
    In:  Europhysics Letters Vol. 135, No. 6 ( 2021-09-01), p. 68001-
    Details
    In: Europhysics Letters, IOP Publishing, Vol. 135, No. 6 ( 2021-09-01), p. 68001-
    Abstract: Taking advantage of the birefringence of crystal, this paper proposes an effective optical system to detect the residual stress at the surface of toughened glass. A theoretical model based on matrix optics is built to describe the optical distribution of a probe light in the system, and the simulation outputs two complementary images whose mode patterns are determined by the phase delay arising from the surface-stress–induced birefringence. The experimental results confirm the simulation results that the mode pattern varies accordingly while the phase delay varies in 2 period. Features of interference fringes are extracted by dedicated image recognition algorithm and form their own feature data sets. Comparing the experimental data sets with the simulation ones, the phase delay of each experimental pattern can be deduced, so the stress of the sample point can be calculated. Our device's surface stress scanning results of toughened glass are very close to the commercial instrument SCALP-04's ones, with the relative deviation between them below 6%. Our system provides an efficient and simple way to measure present stress distribution on the surface of transparent materials, and owing to its fewer instruments involvement, broad detecting distance, and high signal-to-noise ratio, our system can be developed into integrated products. This method can also be applied in different materials such as high polymer, silicide, etc., where only the wavelength of the laser needs to be modified.
    Type of Medium: Online Resource
    ISSN: 0295-5075 , 1286-4854
    URL: Article
    DOI: 10.1209/0295-5075/ac1fa3
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Why posters contribute different content in their positive online reviews: A social information-processing perspective
    Elsevier BV ; 2018
    In:  Computers in Human Behavior Vol. 82 ( 2018-05), p. 199-216
    Details
    In: Computers in Human Behavior, Elsevier BV, Vol. 82 ( 2018-05), p. 199-216
    Type of Medium: Online Resource
    ISSN: 0747-5632
    URL: Article
    DOI: 10.1016/j.chb.2018.01.009
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
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  • 8
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    Atmospheric new particle formation from sulfuric acid and amines in a Chinese megacity
    American Association for the Advancement of Science (AAAS) ; 2018
    In:  Science Vol. 361, No. 6399 ( 2018-07-20), p. 278-281
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 361, No. 6399 ( 2018-07-20), p. 278-281
    Abstract: Atmospheric new particle formation (NPF) is an important global phenomenon that is nevertheless sensitive to ambient conditions. According to both observation and theoretical arguments, NPF usually requires a relatively high sulfuric acid (H 2 SO 4 ) concentration to promote the formation of new particles and a low preexisting aerosol loading to minimize the sink of new particles. We investigated NPF in Shanghai and were able to observe both precursor vapors (H 2 SO 4 ) and initial clusters at a molecular level in a megacity. High NPF rates were observed to coincide with several familiar markers suggestive of H 2 SO 4 –dimethylamine (DMA)–water (H 2 O) nucleation, including sulfuric acid dimers and H 2 SO 4 -DMA clusters. In a cluster kinetics simulation, the observed concentration of sulfuric acid was high enough to explain the particle growth to ~3 nanometers under the very high condensation sink, whereas the subsequent higher growth rate beyond this size is believed to result from the added contribution of condensing organic species. These findings will help in understanding urban NPF and its air quality and climate effects, as well as in formulating policies to mitigate secondary particle formation in China.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aao4839
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2018
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  • 9
    Online Resource
    Online Resource
    Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
    American Association for the Advancement of Science (AAAS) ; 2018
    In:  Science Vol. 359, No. 6380 ( 2018-03-09), p. 1151-1156
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 359, No. 6380 ( 2018-03-09), p. 1151-1156
    Abstract: The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aao5774
    RVK:
    TA 1000
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    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2018
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    detail.hit.zdb_id: 2060783-0
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  • 10
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    Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses
    Proceedings of the National Academy of Sciences ; 2016
    In:  Proceedings of the National Academy of Sciences Vol. 113, No. 2 ( 2016-01-12), p. 392-397
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 113, No. 2 ( 2016-01-12), p. 392-397
    Abstract: Pigs are important intermediate hosts for generating novel influenza viruses. The Eurasian avian-like H1N1 (EAH1N1) swine influenza viruses (SIVs) have circulated in pigs since 1979, and human cases associated with EAH1N1 SIVs have been reported in several countries. However, the biologic properties of EAH1N1 SIVs are largely unknown. Here, we performed extensive influenza surveillance in pigs in China and isolated 228 influenza viruses from 36,417 pigs. We found that 139 of the 228 strains from pigs in 10 provinces in China belong to the EAH1N1 lineage. These viruses formed five genotypes, with two distinct antigenic groups, represented by A/swine/Guangxi/18/2011 and A/swine/Guangdong/104/2013, both of which are antigenically and genetically distinct from the current human H1N1 viruses. Importantly, the EAH1N1 SIVs preferentially bound to human-type receptors, and 9 of the 10 tested viruses transmitted in ferrets by respiratory droplet. We found that 3.6% of children (≤10 y old), 0% of adults, and 13.4% of elderly adults (≥60 y old) had neutralization antibodies (titers ≥40 in children and ≥80 in adults) against the EAH1N1 A/swine/Guangxi/18/2011 virus, but none of them had such neutralization antibodies against the EAH1N1 A/swine/Guangdong/104/2013 virus. Our study shows the potential of EAH1N1 SIVs to transmit efficiently in humans and suggests that immediate action is needed to prevent the efficient transmission of EAH1N1 SIVs to humans.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1522643113
    RVK:
    TA 1000
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    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2016
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