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  • 1
    Online Resource
    Online Resource
    Numerical analysis for attenuation due to sound absorption in small and large closed spaces using finite-element method
    Acoustical Society of America (ASA) ; 2006
    In:  The Journal of the Acoustical Society of America Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3011-3011
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3011-3011
    Abstract: A finite element for media having sound absorption is derived and a code is developed. For this element, an unknown parameter is pressure, and both effective density and bulk modulus of the media have complex quantity to represent damped sound fields. This model for the media having sound absorption was adopted by H. Utsuno’s research group for their boundary element formulation [Utsuno et al., AIAA J. 28(11), 1870–1875 (1990)]. Firstly, a three-dimensional sound field in a small closed space (306×255×204 mm3), containing a sound-absorbing material, is calculated using the finite element method. Validity of the calculated response is verified by comparison with the corresponding experimental result carried by H. Utsuno. Secondly, a two-dimensional sound field in relatively large closed space (about 7×3 m2) is calculated varying damping of its medium. The shape of the large space is rectangle, and the rectangular space has a roof. Distribution of sound pressure is calculated when the velocity of the roof is given as white noise. Under the low damping condition for the medium, distribution of sound pressure is almost uniform like the diffused sound field. Under the high damping condition for the medium, sound pressure become larger when the observation point is closer to the roof.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4787044
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2006
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    Phosholipase C-Related Inactive Protein Is Involved in Trafficking of γ2 Subunit-Containing GABA A Receptors to the Cell Surface
    Society for Neuroscience ; 2007
    In:  The Journal of Neuroscience Vol. 27, No. 7 ( 2007-02-14), p. 1692-1701
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 27, No. 7 ( 2007-02-14), p. 1692-1701
    Abstract: The subunit composition of GABA A receptors is known to be associated with distinct physiological and pharmacological properties. Previous studies that used phospholipase C-related inactive protein type 1 knock-out (PRIP-1 KO) mice revealed that PRIP-1 is involved in the assembly and/or the trafficking of γ2 subunit-containing GABA A receptors. There are two PRIP genes in mammals; thus the roles of PRIP-1 might be compensated partly by those of PRIP-2 in PRIP-1 KO mice. Here we used PRIP-1 and PRIP-2 double knock-out (PRIP-DKO) mice and examined the roles for PRIP in regulating the trafficking of GABA A receptors. Consistent with previous results, sensitivity to diazepam was reduced in electrophysiological and behavioral analyses of PRIP-DKO mice, suggesting an alteration of γ2 subunit-containing GABA A receptors. The surface numbers of diazepam binding sites (α/γ2 subunits) assessed by [ 3 H]flumazenil binding were reduced in the PRIP-DKO mice as compared with those of wild-type mice, whereas the cell surface GABA binding sites (α/β subunits, assessed by [ 3 H]muscimol binding) were increased in PRIP-DKO mice. The association between GABA A receptors and GABA A receptor-associated protein (GABARAP) was reduced significantly in PRIP-DKO neurons. Disruption of the direct interaction between PRIP and GABA A receptor β subunits via the use of a peptide corresponding to the PRIP-1 binding site reduced the cell surface expression of γ2 subunit-containing GABA A receptors in cultured cell lines and neurons. These results suggest that PRIP is implicated in the trafficking of γ2 subunit-containing GABA A receptors to the cell surface, probably by acting as a bridging molecule between GABARAP and the receptors.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    DOI: 10.1523/JNEUROSCI.3155-06.2007
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2007
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Toll ligand Spätzle3 controls melanization in the stripe pattern formation in caterpillars
    Proceedings of the National Academy of Sciences ; 2017
    In:  Proceedings of the National Academy of Sciences Vol. 114, No. 31 ( 2017-08), p. 8336-8341
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 114, No. 31 ( 2017-08), p. 8336-8341
    Abstract: A stripe pattern is an aposematic or camouflage coloration often observed among various caterpillars. However, how this ecologically important pattern is formed is largely unknown. The silkworm dominant mutant Zebra ( Ze ) has a black stripe in the anterior margin of each dorsal segment. Here, fine linkage mapping of 3,135 larvae revealed a 63-kbp region responsible for the Ze locus, which contained three candidate genes, including the Toll ligand gene spätzle3 ( spz-3 ). Both electroporation-mediated ectopic expression and RNAi analyses showed that, among candidate genes, only processed spz-3 induced melanin pigmentation and that Toll-8 was the candidate receptor gene of spz-3 . This Toll ligand/receptor set is also involved in melanization of other mutant Striped ( p S ), which has broader stripes. Additional knockdown of 5 other spz family and 10 Toll- related genes caused no drastic change in the pigmentation of either mutant, suggesting that only spz-3/Toll-8 is mainly involved in the melanization process rather than pattern formation. The downstream pigmentation gene yellow was specifically up-regulated in the striped region of the Ze mutant, but spz-3 showed no such region-specific expression. Toll signaling pathways are known to be involved in innate immunity, dorsoventral axis formation, and neurotrophic functions. This study provides direct evidence that a Toll signaling pathway is co-opted to control the melanization process and adaptive striped pattern formation in caterpillars.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1707896114
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice
    Proceedings of the National Academy of Sciences ; 2005
    In:  Proceedings of the National Academy of Sciences Vol. 102, No. 44 ( 2005-11), p. 15791-15796
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 102, No. 44 ( 2005-11), p. 15791-15796
    Abstract: The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of the core fucose, we generated α1,6-fucosyltransferase ( Fut8 )-null mice and found that disruption of Fut8 induces severe growth retardation and death during postnatal development. Histopathological analysis revealed that Fut8 -/- mice showed emphysema-like changes in the lung, verified by a physiological compliance analysis. Biochemical studies indicated that lungs from Fut8 -/- mice exhibit a marked overexpression of matrix metalloproteinases (MMPs), such as MMP-12 and MMP-13, highly associated with lung-destructive phenotypes, and a down-regulation of extracellular matrix (ECM) proteins such as elastin, as well as retarded alveolar epithelia cell differentiation. These changes should be consistent with a deficiency in TGF-β1 signaling, a pleiotropic factor that controls ECM homeostasis by down-regulating MMP expression and inducing ECM protein components. In fact, Fut8 -/- mice have a marked dysregulation of TGF-β1 receptor activation and signaling, as assessed by TGF-β1 binding assays and Smad2 phosphorylation analysis. We also show that these TGF-β1 receptor defects found in Fut8 -/- cells can be rescued by reintroducing Fut8 into Fut8 -/- cells. Furthermore, exogenous TGF-β1 potentially rescued emphysema-like phenotype and concomitantly reduced MMP expression in Fut8 -/- lung. We propose that the lack of core fucosylation of TGF-β1 receptors is crucial for a developmental and progressive/destructive emphysema, suggesting that perturbation of this function could underlie certain cases of human emphysema.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0507375102
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2005
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Sound radiation from finite plates excited by a space-time stream of random impulses
    Acoustical Society of America (ASA) ; 2006
    In:  The Journal of the Acoustical Society of America Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3345-3345
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3345-3345
    Abstract: Sound radiation from baffled finite elastic plates that are subjected to impulses occurring at random points on the surface, at random intervals, and with random strength is analyzed. The plate response is obtained in the Stieltjes integral form of the plate impulse response function with respect to the occurrence of impulses. The total sound power radiated from the plate is formulated according to Heckl’s approach. Explicit expressions for the expected value of the plate response and the radiated sound power are derived for the case in which the stream of impulses is uncorrelated. An approximate solution for the radiated sound power is obtained by assuming light damping of plates and by neglecting modal coupling effects. For comparison, the exact and approximate solutions are evaluated numerically for a plate with constant loss factors. The analysis is applied to the prediction of rainfall noise by expressing the expected value of the exciting force in terms of the size of raindrops, their terminal velocity, and the rainfall rate.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4781370
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2006
    detail.hit.zdb_id: 1461063-2
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