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  • 1
    Online Resource
    Online Resource
    Early dysautonomia detected by heart rate variability predicts late depression in female patients following mild traumatic brain injury
    Wiley ; 2016
    In:  Psychophysiology Vol. 53, No. 4 ( 2016-04), p. 455-464
    Details
    In: Psychophysiology, Wiley, Vol. 53, No. 4 ( 2016-04), p. 455-464
    Abstract: Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in the autonomic nervous system (ANS) can be evaluated by a noninvasive power spectral analysis of the heart rate variability (HRV). In this study, we investigated whether a frequency‐domain analysis of HRV was correlated with late depression in mTBI patients. In total, 181 patients diagnosed with mTBI and 83 volunteers as healthy controls were recruited in 2010–2014. Beck Depression Inventory (BDI) scores were used to evaluate depression in the 1st week of assessment and at 1.5‐, 3‐, 6‐, 12‐, and 18‐month follow‐ups. Correlation and logistic regression analyses of the 1st week HRV parameters with BDI scores at 18 months were performed in individual female mTBI patients. Female mTBI patients were more vulnerable to depression accompanied by reduced HRV compared to healthy controls. Over time, depression was aggravated in female mTBI patients but was alleviated in male mTBI patients. A significantly lower parasympathetic proportion of the ANS was noted at 18 months with respect to the 1st week in female mTBI patients. In addition, depression in female mTBI patients at 18 months after injury was significantly correlated with a decrease in the parasympathetic proportion of the ANS in the 1st week (ρ = −0.411; p   〈  .05). Dysautonomia resulted in higher risks of depression in female mTBI patients. We concluded that early dysautonomia following an mTBI contributes to late depression in female mTBI patients.
    Type of Medium: Online Resource
    ISSN: 0048-5772 , 1469-8986
    URL: Issue
    URL: Article
    DOI: 10.1111/psyp.2016.53.issue-4
    DOI: 10.1111/psyp.12575
    RVK:
    CL 1000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1484299-3
    SSG: 5,2
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  • 2
    Online Resource
    Online Resource
    ACADEMIC PERFORMANCE ANTECEDENT SCALE: VALIDATION WITH NATIVE AND RECENT IMMIGRANT CHILDREN 1
    SAGE Publications ; 2013
    In:  Psychological Reports ( 2013-07-29), p. 130729083742000-
    Details
    In: Psychological Reports, SAGE Publications, ( 2013-07-29), p. 130729083742000-
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/11.03.PR0.112.3
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Academic Performance Antecedent Scale: Validation with Native and Recent Immigrant Children
    SAGE Publications ; 2013
    In:  Psychological Reports Vol. 112, No. 3 ( 2013-06), p. 732-744
    Details
    In: Psychological Reports, SAGE Publications, Vol. 112, No. 3 ( 2013-06), p. 732-744
    Abstract: This study aims to assess the measurement invariance of the three subscales of the newly developed Academic Performance Antecedent Scale (APAS) — School Factors, Mother's Parenting Style, and Individual Factors—across native and new immigrant children in Taiwan. The study sample comprised 527 Grade 4 students ( M age = 10.4 yr., SD = 0.6), 263 boys and 264 girls. The three groups were urban and rural children of Taiwanese natives ( n = 343, 65.1%), and 184 children with non-Taiwanese mothers (34.9%). The four-factor structure of the School Factors Subscale, the three-factor structure of the Mother's Parenting Style Subscale, and the five-factor structure of the Individual Factors Subscale all showed at least acceptable fit for the groups. In addition, metric invariance was confirmed for the School Factors and Individual Factors Subscales. Metric invariance was partially obtained for the Mother's Parenting Style Subscale. The findings provide validity evidences for cross-cultural generalizability of the APAS.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/11.03.PR0.112.3.732-744
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities
    Proceedings of the National Academy of Sciences ; 2021
    In:  Proceedings of the National Academy of Sciences Vol. 118, No. 21 ( 2021-05-25)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 118, No. 21 ( 2021-05-25)
    Abstract: Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive, although they often show signs of prior clonal expansion. Hypothesizing that this may be due to peripheral tolerance, we formulated nanoparticles containing innate immune stimulants that we found were sufficient to activate self-specific CD8 + T cells and injected them into two different mouse tumor models, B16F10 and MC38. These nanoparticles robustly activated and/or expanded antigen-specific CD8 + tumor-infiltrating T cells, along with a decrease in regulatory CD4 + T cells and an increase in Interleukin-17 producers, resulting in significant tumor growth retardation or elimination and the establishment of immune memory in surviving mice. Furthermore, nanoparticles with modification of stimulating human T cells enabled the robust activation of endogenous T cells in patient-derived tumor organoids. These results indicate that breaking peripheral tolerance without regard to the antigen specificity creates a promising pathway for cancer immunotherapy.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2016168118
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Proceedings of the National Academy of Sciences ; 2005
    In:  Proceedings of the National Academy of Sciences Vol. 102, No. 11 ( 2005-03-15), p. 4134-4139
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 102, No. 11 ( 2005-03-15), p. 4134-4139
    Abstract: Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol–SCAR, we carried out a case-control association study. We enrolled 51 patients with allopurinol–SCAR and 228 control individuals (135 allopurinol-tolerant subjects and 93 healthy subjects from the general population), and genotyped for 823 SNPs in genes related to drug metabolism and immune response. The initial screen revealed strong association between allopurinol–SCAR and SNPs in the MHC region, including BAT3 (encoding HLA-B associated transcript 3), MSH5 (mutS homolog 5), and MICB (MHC class I polypeptide-related sequence B) ( P 〈 10 –7 ). We then determined the alleles of HLA loci A, B, C, and DRB1. The HLA-B*5801 allele was present in all (100%) 51 patients with allopurinol–SCAR, but only in 20 (15%) of 135 tolerant patients [odds ratio 580.3 (95% confidence interval, 34.4–9780.9); corrected P value = 4.7 × 10 –24 ] and in 19 (20%) of 93 of healthy subjects [393.51 (23.23–6665.26); corrected P value = 8.1 × 10 –18 ]. HLA alleles A*3303, Cw*0302, and DRB1*0301 were in linkage disequilibrium and formed an extended haplotype with HLA-B*5801. Our results indicated that allopurinol–SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0409500102
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2005
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    The analysis of elementary and high school students' natural and humorous responses patterns in coping with embarrassing situations
    Walter de Gruyter GmbH ; 2014
    In:  HUMOR Vol. 27, No. 2 ( 2014-01-1)
    Details
    In: HUMOR, Walter de Gruyter GmbH, Vol. 27, No. 2 ( 2014-01-1)
    Abstract: This research aims to examine the use of humor in early adolescents for coping with imagined situations. The main issues investigated are the response patterns of participants to requests to answer the imagined questions by taking both general and humorous perspectives. The Interpersonal Coping Questionnaire was used to survey 485 fifth- to eighth- grade elementary school students in Taipei County and Taipei City for their answers to the imagined questions. The results show that, compared to the general answering perspective, elementary school students taking the humorous answering perspective tended to use specific coping strategies, humor techniques and content. The analysis of techniques of humor in our study has also revealed that irony, imitation, and metaphor were the most used strategies to cope with embarrassing interpersonal conditions in cases where a humorous approach was requested. In terms of age, both male and female junior high school students use more humorous techniques than the fifthand sixth-graders do, indicating a significant correlation between the creation of humor and the development of cognition. In terms of gender, female junior high school students use illogic and parody/imitation more than the male counterparts do. The respondents' humorous responses were also classified as aggressive, affiliative, self-defeating, or self-enhancing. It was discovered in this study that in terms of age, male elementary students mostly frequently used aggressive humor, whereas female elementary students mostly often used affiliative humor responses. As for junior high school students, male students use more aggressive humor, while their female counterparts use more self-defeating humor. These findings of the present research provide a valuable understanding for education.
    Type of Medium: Online Resource
    ISSN: 1613-3722 , 0933-1719
    URL: Article
    DOI: 10.1515/humor-2013-0059
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 2051294-6
    detail.hit.zdb_id: 227662-8
    SSG: 5,2
    SSG: 7,11
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