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  • 1
    Online Resource
    Online Resource
    Simulated Rapid Warming of Abyssal North Pacific Waters
    American Association for the Advancement of Science (AAAS) ; 2010
    In:  Science Vol. 329, No. 5989 ( 2010-07-16), p. 319-322
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 329, No. 5989 ( 2010-07-16), p. 319-322
    Abstract: Recent observational surveys have shown significant oceanic bottom-water warming. However, the mechanisms causing such warming remain poorly understood, and their time scales are uncertain. Here, we report computer simulations that reveal a fast teleconnection between changes in the surface air-sea heat flux off the Adélie Coast of Antarctica and the bottom-water warming in the North Pacific. In contrast to conventional estimates of a multicentennial time scale, this link is established over only four decades through the action of internal waves. Changes in the heat content of the deep ocean are thus far more sensitive to the air-sea thermal interchanges than previously considered. Our findings require a reassessment of the role of the Southern Ocean in determining the impact of atmospheric warming on deep oceanic waters.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1188703
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2010
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion
    American Association for the Advancement of Science (AAAS) ; 1998
    In:  Science Vol. 281, No. 5378 ( 1998-08-07), p. 832-835
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 281, No. 5378 ( 1998-08-07), p. 832-835
    Abstract: The small guanosine triphosphatases (GTPases) Cdc42 and Rac1 regulate E-cadherin–mediated cell-cell adhesion. IQGAP1, a target of Cdc42 and Rac1, was localized with E-cadherin and β-catenin at sites of cell-cell contact in mouse L fibroblasts expressing E-cadherin (EL cells), and interacted with E-cadherin and β-catenin both in vivo and in vitro. IQGAP1 induced the dissociation of α-catenin from a cadherin-catenin complex in vitro and in vivo. Overexpression of IQGAP1 in EL cells, but not in L cells expressing an E-cadherin–α-catenin chimeric protein, resulted in a decrease in E-cadherin–mediated cell-cell adhesive activity. Thus, IQGAP1, acting downstream of Cdc42 and Rac1, appears to regulate cell-cell adhesion through the cadherin-catenin pathway.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.281.5378.832
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 1998
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Stereophonic reproduction based on multi-beam-forming with curved-type parametric array loudspeaker
    Acoustical Society of America (ASA) ; 2016
    In:  Journal of the Acoustical Society of America Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3059-3059
    Details
    In: Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3059-3059
    Abstract: A parametric array loudspeaker (PAL) has a flat surface arrangement of ultrasonic transducers and achieves a sharper directivity by utilizing an ultrasound wave. It can form a narrow audible space called an “audio spot” that can provide a target sound to a particular listener. In addition, the PAL can achieve a stereophonic reproduction by designing the audio spots for the positions of ears on the basis of delay-and-sum beamforming. However, designing wider audio spots for several listeners is difficult for the conventional PAL because it has overly sharp directivity. To solve this problem, we propose a new stereophonic reproduction with a curved-type PAL that can expand the audio spots. The curved-type PAL consists of ultrasonic transducers arranged on a concave surface. It can form a wider directivity compared with the conventional flat-type PAL. The proposed method steers the acoustic beam by designing the focal point to the positions of ears, and the radius of the curved-type PAL varies the width of the acoustic-beams. In this study, we carried out an objective evaluation experiment to confirm the effectiveness of the proposed method. As a result, we confirmed that the proposed method can design two wider acoustic beams for the stereophonic reproduction.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4969515
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2016
    detail.hit.zdb_id: 1461063-2
    Location Call Number Limitation Availability
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  • 4
    Online Resource
    Online Resource
    Rhodopsin-mediated light-off-induced protein kinase A activation in mouse rod photoreceptor cells
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 43 ( 2020-10-27), p. 26996-27003
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 43 ( 2020-10-27), p. 26996-27003
    Abstract: Light-induced extrasynaptic dopamine release in the retina reduces adenosine 3′,5′-cyclic monophosphate (cAMP) in rod photoreceptor cells, which is thought to mediate light-dependent desensitization. However, the fine time course of the cAMP dynamics in rods remains elusive due to technical difficulty. Here, we visualized the spatiotemporal regulation of cAMP-dependent protein kinase (PKA) in mouse rods by two-photon live imaging of retinal explants of PKAchu mice, which express a fluorescent biosensor for PKA. Unexpectedly, in addition to the light-on-induced suppression, we observed prominent light-off-induced PKA activation. This activation required photopic light intensity and was confined to the illuminated rods. The estimated maximum spectral sensitivity of 489 nm and loss of the light-off-induced PKA activation in rod-transducin-knockout retinas strongly suggest the involvement of rhodopsin. In support of this notion, rhodopsin-deficient retinal explants showed only the light-on-induced PKA suppression. Taken together, these results suggest that, upon photopic light stimulation, rhodopsin and dopamine signals are integrated to shape the light-off-induced cAMP production and following PKA activation. This may support the dark adaptation of rods.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2009164117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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