In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 68, No. 1 ( 1971-01), p. 6-9
Abstract:
The DNA of Escherichia coli has been isolated in a compact structure containing small amounts of protein and RNA and having a sedimentation coefficient of approximately 3200 S. The molecular weight of the DNA in the complex is very large (probably higher than 10 9 ); the protein is predominantly core RNA polymerase; the RNA is chiefly nascent messenger and ribosomal chains. Solutions containing the complex have low viscosities; this plus its sedimentation rate suggest that the DNA is in a tightly folded conformation. The DNA unfolds after exposure to RNase or heat; this indicates that an RNA component of the complex is involved in stabilizing the structure.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
1971
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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